Nicholas H Keep
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Explore the profile of Nicholas H Keep including associated specialties, affiliations and a list of published articles.
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35
Citations
1083
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Recent Articles
11.
Densham R, Garvin A, Stone H, Strachan J, Baldock R, Daza-Martin M, et al.
Nat Struct Mol Biol
. 2016 May;
23(7):647-55.
PMID: 27239795
The opposing activities of 53BP1 and BRCA1 influence pathway choice in DNA double-strand-break repair. How BRCA1 counteracts the inhibitory effect of 53BP1 on DNA resection and homologous recombination is unknown....
12.
Northey T, Venthur H, De Biasio F, Chauviac F, Cole A, Ribeiro Junior K, et al.
Sci Rep
. 2016 Apr;
6:24739.
PMID: 27102935
Aphids use chemical cues to locate hosts and find mates. The vetch aphid Megoura viciae feeds exclusively on the Fabaceae, whereas the currant-lettuce aphid Nasonovia ribisnigri alternates hosts between the...
13.
Quay D, Cole A, Cryar A, Thalassinos K, Williams M, Bhakta S, et al.
BMC Struct Biol
. 2015 Jul;
15:12.
PMID: 26163297
Background: Stationary phase survival proteins (Sps) were found in Firmicutes as having analogous domain compositions, and in some cases genome context, as the resuscitation promoting factors of Actinobacteria, but with...
14.
Lichman B, Gershater M, Lamming E, Pesnot T, Sula A, Keep N, et al.
FEBS J
. 2015 Jan;
282(6):1137-51.
PMID: 25620686
Norcoclaurine synthase (NCS) (EC 4.2.1.78) catalyzes the Pictet-Spengler condensation of dopamine and an aldehyde, forming a substituted (S)-tetrahydroisoquinoline, a pharmaceutically important moiety. This unique activity has led to NCS being...
15.
Chauviac F, Robertson G, Quay D, Bagneris C, Dumas C, Henderson B, et al.
Acta Crystallogr F Struct Biol Commun
. 2014 Aug;
70(Pt 8):1022-6.
PMID: 25084374
The first structure of the catalytic domain of RpfC (Rv1884), one of the resuscitation-promoting factors (RPFs) from Mycobacterium tuberculosis, is reported. The structure was solved using molecular replacement once the...
16.
Sula A, Cole A, Yeats C, Orengo C, Keep N
BMC Struct Biol
. 2014 Jan;
14:3.
PMID: 24438169
Background: Mutations in dysferlin, the first protein linked with the cell membrane repair mechanism, causes a group of muscular dystrophies called dysferlinopathies. Dysferlin is a type two-anchored membrane protein, with...
17.
Zihni C, Munro P, Elbediwy A, Keep N, Terry S, Harris J, et al.
J Cell Biol
. 2014 Jan;
204(1):111-27.
PMID: 24379416
Epithelial cells develop morphologically characteristic apical domains that are bordered by tight junctions, the apical-lateral border. Cdc42 and its effector complex Par6-atypical protein kinase c (aPKC) regulate multiple steps during...
18.
Munshi T, Gupta A, Evangelopoulos D, Guzman J, Gibbons S, Keep N, et al.
PLoS One
. 2013 Apr;
8(3):e60143.
PMID: 23555903
ATP-dependent Mur ligases (Mur synthetases) play essential roles in the biosynthesis of cell wall peptidoglycan (PG) as they catalyze the ligation of key amino acid residues to the stem peptide...
19.
Chauviac F, Bommer M, Yan J, Parkin G, Daviter T, Lowden P, et al.
J Biol Chem
. 2012 Nov;
287(53):44372-83.
PMID: 23148223
This paper presents the structure of MsAcg (MSMEG_5246), a Mycobacterium smegmatis homologue of Mycobacterium tuberculosis Acg (Rv2032) in its reduced form at 1.6 Å resolution using x-ray crystallography. Rv2032 is...
20.
Evangelopoulos D, Cronin N, Daviter T, Sim E, Keep N, Bhakta S
FEBS J
. 2011 Oct;
278(24):4824-32.
PMID: 21972977
Mycobacterium tuberculosis, the most successful bacterial pathogen, causes tuberculosis, a disease that still causes more than 2 million deaths per year. Arylamine N-acetyltransferase is an enzyme that is conserved in...