Benjamin R Lichman
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Explore the profile of Benjamin R Lichman including associated specialties, affiliations and a list of published articles.
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Articles
30
Citations
362
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Recent Articles
1.
Kamileen M, Nakamura Y, Luck K, Heinicke S, Hong B, Colinas M, et al.
New Phytol
. 2024 Sep;
244(4):1437-1449.
PMID: 39285533
Plant-specialized metabolism is largely driven by the oxidative tailoring of key chemical scaffolds catalyzed by cytochrome P450 (CYP450s) enzymes. Monoterpene indole alkaloids (MIAs) tabersonine and pseudo-tabersonine, found in the medicinal...
2.
Grzech D, Smit S, Alam R, Boccia M, Nakamura Y, Hong B, et al.
Nat Chem Biol
. 2024 Sep;
21(1):131-142.
PMID: 39271954
Steroidal glycoalkaloids (SGAs) are specialized metabolites produced by hundreds of Solanum species including food crops, such as tomato, potato and eggplant. Unlike true alkaloids, nitrogen is introduced at a late...
3.
Smit S, Whitehead C, James S, Jeffares D, Godden G, Peng D, et al.
G3 (Bethesda)
. 2024 Jul;
14(10).
PMID: 39047060
The Nepetoideae, a subfamily of Lamiaceae (mint family), is rich in aromatic plants, many of which are sought after for their use as flavors and fragrances or for their medicinal...
4.
Swamidatta S, Lichman B
Curr Opin Biotechnol
. 2024 Jun;
88:103147.
PMID: 38833915
Plant natural products have been an important source of medicinal molecules since ancient times. To gain access to the whole diversity of these molecules for pharmaceutical applications, it is important...
5.
Eljounaidi K, Radzikowska B, Whitehead C, Taylor D, Conde S, Davis W, et al.
New Phytol
. 2024 May;
243(1):299-313.
PMID: 38757546
Daphniphyllum macropodum produces alkaloids that are structurally complex with polycyclic, stereochemically rich carbon skeletons. Understanding how these compounds are formed by the plant may enable exploration of their biological function...
6.
Smit S, Ayten S, Radzikowska B, Hamilton J, Langer S, Unsworth W, et al.
Plant J
. 2024 Mar;
118(5):1589-1602.
PMID: 38489316
Iridoids are non-canonical monoterpenoids produced by both insects and plants. An example is the cat-attracting and insect-repelling volatile iridoid nepetalactone, produced by Nepeta sp. (catmint) and aphids. Recently, both nepetalactone...
7.
Roddan R, Sula A, Mendez-Sanchez D, Subrizi F, Lichman B, Broomfield J, et al.
Commun Chem
. 2023 Jan;
3(1):170.
PMID: 36703392
The 1-aryl-tetrahydroisoquinoline (1-aryl-THIQ) moiety is found in many biologically active molecules. Single enantiomer chemical syntheses are challenging and although some biocatalytic routes have been reported, the substrate scope is limited...
8.
Liu C, Smit S, Dang J, Zhou P, Godden G, Jiang Z, et al.
Mol Plant
. 2023 Jan;
16(3):533-548.
PMID: 36609143
Biosynthetic gene clusters (BGCs) are regions of a genome where genes involved in a biosynthetic pathway are in proximity. The origin and evolution of plant BGCs as well as their...
9.
Kamileen M, DeMars 2nd M, Hong B, Nakamura Y, Paetz C, Lichman B, et al.
J Am Chem Soc
. 2022 Oct;
144(43):19673-19679.
PMID: 36240425
Nature uses cycloaddition reactions to generate complex natural product scaffolds. Dehydrosecodine is a highly reactive biosynthetic intermediate that undergoes cycloaddition to generate several alkaloid scaffolds that are the precursors to...
10.
Hernandez Lozada N, Hong B, Wood J, Caputi L, Basquin J, Chuang L, et al.
Nat Commun
. 2022 Sep;
13(1):5678.
PMID: 36167838
No abstract available.