Nicholas H Keep
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Explore the profile of Nicholas H Keep including associated specialties, affiliations and a list of published articles.
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35
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1083
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Recent Articles
21.
Basavannacharya C, Moody P, Munshi T, Cronin N, Keep N, Bhakta S
Protein Cell
. 2010 Dec;
1(11):1011-22.
PMID: 21153518
The emergence of total drug-resistant tuberculosis (TDRTB) has made the discovery of new therapies for tuberculosis urgent. The cytoplasmic enzymes of peptidoglycan biosynthesis have generated renewed interest as attractive targets...
22.
ATP-dependent MurE ligase in Mycobacterium tuberculosis: biochemical and structural characterisation
Basavannacharya C, Robertson G, Munshi T, Keep N, Bhakta S
Tuberculosis (Edinb)
. 2009 Dec;
90(1):16-24.
PMID: 19945347
New therapies are required against Mycobacterium tuberculosis and its cell wall peptidoglycan biosynthesis is a potential therapeutic target. UDP-MurNAc-tripeptide ligase (MurE) is a member of the ATP-dependent ligase family, which...
23.
Zhou J, Robertson G, He X, Dufour S, Hooper A, Pickett J, et al.
J Mol Biol
. 2009 Apr;
389(3):529-45.
PMID: 19371749
In many insect species, odorant-binding proteins (OBPs) are thought to be responsible for the transport of pheromones and other semiochemicals across the sensillum lymph to the olfactory receptors (ORs) within...
24.
Patel P, Harris R, Geddes S, Strehle E, Watson J, Bashir R, et al.
J Mol Biol
. 2008 May;
379(5):981-90.
PMID: 18495154
Mutations in the protein dysferlin, a member of the ferlin family, lead to limb girdle muscular dystrophy type 2B and Myoshi myopathy. The ferlins are large proteins characterised by multiple...
25.
Guerrera I, Keep N, Godovac-Zimmermann J
J Proteome Res
. 2007 May;
6(7):2623-30.
PMID: 17506542
Following stimulation of NRK49F rat kidney fibroblast cells with epidermal growth factor, possible preemptive cross-talk between arginine methylation and serine and tyrosine phosphorylation was observed for Rho guanidine nucleotide dissociation...
26.
Keep N, Ward J, Cohen-Gonsaud M, Henderson B
Trends Microbiol
. 2006 May;
14(6):271-6.
PMID: 16675219
When stressed, bacteria can enter various non-dividing states, which are medically important. For example, dormancy is used by Mycobacterium tuberculosis to evade host responses. A major breakthrough has been the...
27.
Morris J, Pangon L, Boutell C, Katagiri T, Keep N, Solomon E
Hum Mol Genet
. 2006 Jan;
15(4):599-606.
PMID: 16403807
The N-terminus of the Breast Cancer-1 predisposition protein (BRCA1) associates with the BRCA1-associated RING domain-1 protein (BARD1) to form a heterodimer, which exhibits ubiquitin ligase activity that is abrogated by...
28.
Kennaway C, Benesch J, Gohlke U, Wang L, Robinson C, Orlova E, et al.
J Biol Chem
. 2005 Jul;
280(39):33419-25.
PMID: 16046399
Small heat shock proteins are a ubiquitous and diverse family of stress proteins that have in common an alpha-crystallin domain. Mycobacterium tuberculosis has two small heat shock proteins, Acr1 (alpha-crystallin-related...
29.
Cohen-Gonsaud M, Barthe P, Pommier F, Harris R, Driscoll P, Keep N, et al.
J Biomol NMR
. 2005 Mar;
30(3):373-4.
PMID: 15754060
No abstract available.
30.
Cohen-Gonsaud M, Barthe P, Bagneris C, Henderson B, Ward J, Roumestand C, et al.
Nat Struct Mol Biol
. 2005 Feb;
12(3):270-3.
PMID: 15723078
Resuscitation-promoting factor (RPF) proteins reactivate stationary-phase cultures of (G+C)-rich Gram-positive bacteria including the causative agent of tuberculosis, Mycobacterium tuberculosis. We report the solution structure of the RPF domain from M....