Nicholas D Kindon
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Explore the profile of Nicholas D Kindon including associated specialties, affiliations and a list of published articles.
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13
Citations
68
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Recent Articles
1.
Patera F, Mistry S, Kindon N, Comeo E, Goulding J, Kellam B, et al.
Pharmacol Res Perspect
. 2024 Jul;
12(4):e1223.
PMID: 39031734
Fluorescent ligands have proved to be powerful tools in the study of G protein-coupled receptors in living cells. Here we have characterized a new fluorescent ligand PSB603-BY630 that has high...
2.
Comeo E, Goulding J, Lin C, Groenen M, Woolard J, Kindon N, et al.
J Med Chem
. 2024 Jul;
67(14):12099-12117.
PMID: 38994645
The study of protein function and dynamics in their native cellular environment is essential for progressing fundamental science. To overcome the requirement of genetic modification of the protein or the...
3.
White C, Platt S, Kilpatrick L, Dale N, Abhayawardana R, Dekkers S, et al.
Sci Signal
. 2024 Mar;
17(828):eabl3758.
PMID: 38502733
CXCL17 is a chemokine principally expressed by mucosal tissues, where it facilitates chemotaxis of monocytes, dendritic cells, and macrophages and has antimicrobial properties. CXCL17 is also implicated in the pathology...
4.
Dekkers S, Caspar B, Goulding J, Kindon N, Kilpatrick L, Stoddart L, et al.
J Med Chem
. 2023 Mar;
66(7):5208-5222.
PMID: 36944083
The C-X-C chemokine receptor type 4, or CXCR4, is a chemokine receptor found to promote cancer progression and metastasis of various cancer cell types. To investigate the pharmacology of this...
5.
Comeo E, Trinh P, Nguyen A, Nowell C, Kindon N, Soave M, et al.
J Med Chem
. 2021 Mar;
64(10):6670-6695.
PMID: 33724031
The adenosine A receptor (AAR) is a G-protein-coupled receptor (GPCR) that provides important therapeutic opportunities for a number of conditions including congestive heart failure, tachycardia, and neuropathic pain. The development...
6.
Stoddart L, Kindon N, Otun O, Harwood C, Patera F, Veprintsev D, et al.
Commun Biol
. 2020 Nov;
3(1):722.
PMID: 33247190
To study the localisation of G protein-coupled receptors (GPCR) in their native cellular environment requires their visualisation through fluorescent labelling. To overcome the requirement for genetic modification of the receptor...
7.
Comeo E, Kindon N, Soave M, Stoddart L, Kilpatrick L, Scammells P, et al.
J Med Chem
. 2019 Dec;
63(5):2656-2672.
PMID: 31887252
Among class A G protein-coupled receptors (GPCR), the human adenosine A receptor (hAAR) remains an attractive drug target. However, translation of AAR ligands into the clinic has proved challenging and...
8.
Conroy S, Kindon N, Glenn J, Stoddart L, Lewis R, Hill S, et al.
J Med Chem
. 2018 Apr;
61(9):4272.
PMID: 29688707
No abstract available.
9.
Conroy S, Kindon N, Glenn J, Stoddart L, Lewis R, Hill S, et al.
J Med Chem
. 2018 Mar;
61(7):3089-3113.
PMID: 29558126
The human P2Y receptor ( hP2YR) is a G-protein-coupled receptor that shows promise as a therapeutic target for many important conditions, including for antimetastatic cancer and more recently for idiopathic...
10.
Schwehm C, Kellam B, Garces A, Hill S, Kindon N, Bradshaw T, et al.
J Med Chem
. 2017 Jan;
60(4):1534-1554.
PMID: 28128944
A novel molecular scaffold has been synthesized, and its incorporation into new analogues of biologically active molecules across multiple target classes will be discussed. In these studies, we have shown...