Michael J Stocks
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Explore the profile of Michael J Stocks including associated specialties, affiliations and a list of published articles.
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52
Citations
388
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Recent Articles
1.
Ji L, Feng W, Chen H, Chu Y, Wong A, Zhu Y, et al.
Int J Pharm
. 2024 Nov;
668:124947.
PMID: 39550011
Due to high lipophilicity and extensive first-pass metabolic loss, cannabidiol (CBD) has low oral bioavailability. Co-administration of CBD and long-chain lipids facilitates the intestinal lymphatic delivery, resulting in higher systemic...
2.
Chen H, Ji L, Wong A, Chu Y, Feng W, Zhu Y, et al.
Int J Pharm
. 2024 Nov;
667(Pt A):124895.
PMID: 39486489
Intestinal lymph nodes are involved in the progression of colorectal cancer (CRC). Tumours suppress the activation of dendritic cells (DCs) in draining lymph nodes, diminishing anti-cancer immune response. Imiquimod (IMQ)...
3.
Wang D, Pattenden G, Fow K, Stocks M, Hirst J, Tang B
J Org Chem
. 2024 Sep;
89(18):12946-12956.
PMID: 39248097
Density functional theory (B3LYP-D3(BJ) and ωB97XD) calculations have been used to assess the stereochemical outcomes of the proposed transannular [4 + 2] cycloaddition pathway for the biosynthesis of mandapamate and...
4.
Knight R, Kilpatrick L, Hill S, Stocks M
ACS Med Chem Lett
. 2024 Jul;
15(7):1127-1135.
PMID: 39015271
The P2Y receptor (P2YR) is a target for diseases including cancer, idiopathic pulmonary fibrosis, and atherosclerosis. However, there are insufficient P2YR antagonists available for validating P2YR function and future drug...
5.
Allison M, Davie R, Mogg A, Hampton S, Emsley J, Stocks M
ACS Med Chem Lett
. 2024 Apr;
15(4):501-509.
PMID: 38628785
Hereditary angioedema (HAE), a rare genetic disorder, is associated with uncontrolled plasma kallikrein (PKa) enzyme activity leading to the generation of bradykinin swelling in subcutaneous and submucosal membranes in various...
6.
White C, Platt S, Kilpatrick L, Dale N, Abhayawardana R, Dekkers S, et al.
Sci Signal
. 2024 Mar;
17(828):eabl3758.
PMID: 38502733
CXCL17 is a chemokine principally expressed by mucosal tissues, where it facilitates chemotaxis of monocytes, dendritic cells, and macrophages and has antimicrobial properties. CXCL17 is also implicated in the pathology...
7.
Dekkers S, Comez D, Karsai N, Arimont-Segura M, Canals M, Caspar B, et al.
ACS Med Chem Lett
. 2024 Jan;
15(1):143-148.
PMID: 38229752
The atypical chemokine receptor 3 (ACKR3) is a receptor that induces cancer progression and metastasis in multiple cell types. Therefore, new chemical tools are required to study the role of...
8.
Soukarieh F, Mashabi A, Richardson W, Oton E, Romero M, Dubern J, et al.
J Med Chem
. 2024 Jan;
67(2):1008-1023.
PMID: 38170170
is one of the top priority pathogens that requires immediate attention according to the World Health Organisation (WHO). Due to the alarming shortage of novel antimicrobials, targeting quorum sensing (QS),...
9.
Wong A, Chu Y, Chen H, Feng W, Ji L, Qin C, et al.
Int J Pharm
. 2023 Nov;
648:123574.
PMID: 37935311
Efficient delivery of antiretroviral agents to lymph nodes is important to decrease the size of the HIV reservoir within the lymphatic system. Lamivudine (3TC) is used in first-line regimens for...
10.
Chu Y, Wong A, Chen H, Ji L, Qin C, Feng W, et al.
Eur J Pharm Biopharm
. 2023 Aug;
191:90-102.
PMID: 37634824
The establishment of latent cellular and anatomical viral reservoirs is a major obstacle to achieving a cure for people infected by HIV. Mesenteric lymph nodes (MLNs) are one of the...