Amelie V Guitart
Overview
Explore the profile of Amelie V Guitart including associated specialties, affiliations and a list of published articles.
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16
Citations
628
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Recent Articles
1.
Lawson H, Holt-Martyn J, Dembitz V, Kabayama Y, Wang L, Bellani A, et al.
Nat Cancer
. 2024 Apr;
5(6):916-937.
PMID: 38637657
Acute myeloid leukemia (AML) is a largely incurable disease, for which new treatments are urgently needed. While leukemogenesis occurs in the hypoxic bone marrow, the therapeutic tractability of the hypoxia-inducible...
2.
Lawson H, van de Lagemaat L, Barile M, Tavosanis A, Durko J, Villacreces A, et al.
Stem Cell Reports
. 2021 Oct;
16(11):2784-2797.
PMID: 34715054
Hematopoietic stem cells (HSCs) reside at the apex of the hematopoietic differentiation hierarchy and sustain multilineage hematopoiesis. Here, we show that the transcriptional regulator CITED2 is essential for life-long HSC...
3.
Dumas P, Villacreces A, Guitart A, El-Habhab A, Massara L, Mansier O, et al.
Clin Cancer Res
. 2021 Aug;
27(21):6012-6025.
PMID: 34400415
Purpose: AXL has been shown to play a pivotal role in the selective response of -ITD acute myeloid leukemia (AML) cells to FLT3 tyrosine kinase inhibitors (TKI), particularly within the...
4.
Rodriguez L, Duchez P, Touya N, Debeissat C, Guitart A, Pasquet J, et al.
Biomolecules
. 2021 Apr;
11(4).
PMID: 33920203
Alpha tocopherol acetate (αTOA) is an analogue of alpha tocopherol (αTOC) that exists in the form of an injectable drug. In the context of the metabolic hypothesis of stem cells,...
5.
Lawson H, Sepulveda C, van de Lagemaat L, Durko J, Barile M, Tavosanis A, et al.
Blood Adv
. 2021 Feb;
5(3):889-899.
PMID: 33560400
Lifelong multilineage hematopoiesis critically depends on rare hematopoietic stem cells (HSCs) that reside in the hypoxic bone marrow microenvironment. Although the role of the canonical oxygen sensor hypoxia-inducible factor prolyl...
6.
Mansier O, Kilani B, Guitart A, Guy A, Gourdou-Latyszenok V, Marty C, et al.
Blood
. 2019 Nov;
134(26):2383-2387.
PMID: 31697834
The major weakness of most knock-in JAK2V617F mouse models is the presence of the JAK2 mutation in all rather than in a few hematopoietic stem cells (HSC), such as in...
7.
Fernandez S, Desplat V, Villacreces A, Guitart A, Milpied N, Pigneux A, et al.
Int J Mol Sci
. 2019 Jul;
20(14).
PMID: 31336846
Acute myeloid leukemia (AML) is a myeloid malignancy carrying a heterogeneous molecular panel of mutations participating in the blockade of differentiation and the increased proliferation of myeloid hematopoietic stem and...
8.
Paris J, Morgan M, Campos J, Spencer G, Shmakova A, Ivanova I, et al.
Cell Stem Cell
. 2019 Apr;
25(1):137-148.e6.
PMID: 31031138
Acute myeloid leukemia (AML) is an aggressive clonal disorder of hematopoietic stem cells (HSCs) and primitive progenitors that blocks their myeloid differentiation, generating self-renewing leukemic stem cells (LSCs). Here, we...
9.
Guitart A, Finch A, Kranc K
J Exp Med
. 2018 Jul;
215(8):1971-1973.
PMID: 30002075
In this issue of , Umemoto et al. (https://doi.org/10.1084/jem.20180421) demonstrate that calcium influx stimulates mitochondrial metabolism and initiates proliferation in hematopoietic stem cells (HSCs). Extracellular adenosine, sourced from surrounding hematopoietic...
10.
Guitart A, Panagopoulou T, Villacreces A, Vukovic M, Sepulveda C, Allen L, et al.
J Exp Med
. 2017 Feb;
214(3):719-735.
PMID: 28202494
Strict regulation of stem cell metabolism is essential for tissue functions and tumor suppression. In this study, we investigated the role of fumarate hydratase (Fh1), a key component of the...