» Authors » Nathaniel S Woodling

Nathaniel S Woodling

Explore the profile of Nathaniel S Woodling including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 26
Citations 854
Followers 0
Related Specialties
Top 10 Co-Authors
Published In
Affiliations
Soon will be listed here.
Recent Articles
1.
Catterson J, Minkley L, Aspe S, Judd-Mole S, Moura S, Dyson M, et al.
Neurobiol Aging . 2023 Oct; 132:154-174. PMID: 37837732
Amyloid β (Aβ) accumulation is a hallmark of Alzheimer's disease. In adult Drosophila brains, human Aβ overexpression harms climbing and lifespan. It's uncertain whether Aβ is intrinsically toxic or activates...
2.
Sahota V, Stone A, Woodling N, Spiers J, Steinert J, Partridge L, et al.
Open Biol . 2023 Sep; 13(9):230171. PMID: 37699519
Alterations in the neuromuscular system underlie several neuromuscular diseases and play critical roles in the development of sarcopenia, the age-related loss of muscle mass and function. Mammalian Myostatin (MST) and...
3.
Anoar S, Woodling N, Niccoli T
Front Neurosci . 2021 Dec; 15:786076. PMID: 34899176
Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are neurodegenerative disorders characterized by declining motor and cognitive functions. Even though these diseases present with distinct sets of symptoms, FTD and...
4.
Bolukbasi E, Woodling N, Ivanov D, Adcott J, Foley A, Rajasingam A, et al.
Proc Natl Acad Sci U S A . 2021 Feb; 118(8). PMID: 33593901
Reduced activity of insulin/insulin-like growth factor signaling (IIS) increases healthy lifespan among diverse animal species. Downstream of IIS, multiple evolutionarily conserved transcription factors (TFs) are required; however, distinct TFs are...
5.
Bjedov I, Cocheme H, Foley A, Wieser D, Woodling N, Castillo-Quan J, et al.
PLoS Genet . 2020 Nov; 16(11):e1009083. PMID: 33253201
Increased cellular degradation by autophagy is a feature of many interventions that delay ageing. We report here that increased autophagy is necessary for reduced insulin-like signalling (IIS) to extend lifespan...
6.
Woodling N, Rajasingam A, Minkley L, Rizzo A, Partridge L
BMC Biol . 2020 Sep; 18(1):124. PMID: 32928209
Background: The increasing age of global populations highlights the urgent need to understand the biological underpinnings of ageing. To this end, inhibition of the insulin/insulin-like signalling (IIS) pathway can extend...
7.
Yu Y, Niccoli T, Ren Z, Woodling N, Aleyakpo B, Szabadkai G, et al.
Hum Mol Genet . 2020 Jun; 29(14):2420-2434. PMID: 32592479
Alzheimer's disease (AD) is the most common form of dementia and the most prevalent neurodegenerative disease. Genome-wide association studies have linked PICALM to AD risk. PICALM has been implicated in...
8.
Woodling N, Aleyakpo B, Dyson M, Minkley L, Rajasingam A, Dobson A, et al.
Aging Cell . 2020 Apr; 19(5):e13137. PMID: 32291952
Inhibition of signalling through several receptor tyrosine kinases (RTKs), including the insulin-like growth factor receptor and its orthologues, extends healthy lifespan in organisms from diverse evolutionary taxa. This raises the...
9.
Gray S, Kinghorn K, Woodling N
Neural Regen Res . 2020 Jan; 15(7):1208-1219. PMID: 31960800
Alzheimer's disease is the leading cause of dementia. Its increased prevalence in developed countries, due to the sharp rise in ageing populations, presents one of the costliest challenges to modern...
10.
Woodling N, Partridge L
Neuron . 2018 Jun; 98(6):1059-1061. PMID: 29953866
Parkinson's disease patients report sleep disturbances well ahead of motor symptoms. In this issue of Neuron, Valadas et al. (2018) report that the disease genes pink1 and parkin exert novel,...