Arjunan Rajasingam
Overview
Explore the profile of Arjunan Rajasingam including associated specialties, affiliations and a list of published articles.
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5
Citations
90
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Recent Articles
1.
Catterson J, Minkley L, Aspe S, Judd-Mole S, Moura S, Dyson M, et al.
Neurobiol Aging
. 2023 Oct;
132:154-174.
PMID: 37837732
Amyloid β (Aβ) accumulation is a hallmark of Alzheimer's disease. In adult Drosophila brains, human Aβ overexpression harms climbing and lifespan. It's uncertain whether Aβ is intrinsically toxic or activates...
2.
Bolukbasi E, Woodling N, Ivanov D, Adcott J, Foley A, Rajasingam A, et al.
Proc Natl Acad Sci U S A
. 2021 Feb;
118(8).
PMID: 33593901
Reduced activity of insulin/insulin-like growth factor signaling (IIS) increases healthy lifespan among diverse animal species. Downstream of IIS, multiple evolutionarily conserved transcription factors (TFs) are required; however, distinct TFs are...
3.
Woodling N, Rajasingam A, Minkley L, Rizzo A, Partridge L
BMC Biol
. 2020 Sep;
18(1):124.
PMID: 32928209
Background: The increasing age of global populations highlights the urgent need to understand the biological underpinnings of ageing. To this end, inhibition of the insulin/insulin-like signalling (IIS) pathway can extend...
4.
Woodling N, Aleyakpo B, Dyson M, Minkley L, Rajasingam A, Dobson A, et al.
Aging Cell
. 2020 Apr;
19(5):e13137.
PMID: 32291952
Inhibition of signalling through several receptor tyrosine kinases (RTKs), including the insulin-like growth factor receptor and its orthologues, extends healthy lifespan in organisms from diverse evolutionary taxa. This raises the...
5.
Catterson J, Khericha M, Dyson M, Vincent A, Callard R, Haveron S, et al.
Curr Biol
. 2018 May;
28(11):1714-1724.e4.
PMID: 29779873
Intermittent fasting (IF) can improve function and health during aging in laboratory model organisms, but the mechanisms at work await elucidation. We subjected fruit flies (Drosophila melanogaster) to varying degrees...