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Benjamin Aleyakpo

Explore the profile of Benjamin Aleyakpo including associated specialties, affiliations and a list of published articles. Areas
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Articles 7
Citations 36
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Recent Articles
1.
OFarrell F, Aleyakpo B, Mustafa R, Jiang X, Pinto R, Elliott P, et al.
Sci Rep . 2023 Nov; 13(1):20616. PMID: 37996473
Biological pathways between alcohol consumption and alcohol liver disease (ALD) are not fully understood. We selected genes with known effect on (1) alcohol consumption, (2) liver function, and (3) gene...
2.
Xu D, Vincent A, Gonzalez-Gutierrez A, Aleyakpo B, Anoar S, Giblin A, et al.
PLoS Genet . 2023 Sep; 19(9):e1010893. PMID: 37733679
Brains are highly metabolically active organs, consuming 20% of a person's energy at resting state. A decline in glucose metabolism is a common feature across a number of neurodegenerative diseases....
3.
Niccoli T, Kerr F, Snoeren I, Fabian D, Aleyakpo B, Ivanov D, et al.
Brain Commun . 2021 May; 3(2):fcab053. PMID: 33977265
Accumulation of amyloid beta peptides is thought to initiate the pathogenesis of Alzheimer's disease. However, the precise mechanisms mediating their neurotoxicity are unclear. Our microarray analyses show that, in models...
4.
Bolukbasi E, Woodling N, Ivanov D, Adcott J, Foley A, Rajasingam A, et al.
Proc Natl Acad Sci U S A . 2021 Feb; 118(8). PMID: 33593901
Reduced activity of insulin/insulin-like growth factor signaling (IIS) increases healthy lifespan among diverse animal species. Downstream of IIS, multiple evolutionarily conserved transcription factors (TFs) are required; however, distinct TFs are...
5.
Yu Y, Niccoli T, Ren Z, Woodling N, Aleyakpo B, Szabadkai G, et al.
Hum Mol Genet . 2020 Jun; 29(14):2420-2434. PMID: 32592479
Alzheimer's disease (AD) is the most common form of dementia and the most prevalent neurodegenerative disease. Genome-wide association studies have linked PICALM to AD risk. PICALM has been implicated in...
6.
Woodling N, Aleyakpo B, Dyson M, Minkley L, Rajasingam A, Dobson A, et al.
Aging Cell . 2020 Apr; 19(5):e13137. PMID: 32291952
Inhibition of signalling through several receptor tyrosine kinases (RTKs), including the insulin-like growth factor receptor and its orthologues, extends healthy lifespan in organisms from diverse evolutionary taxa. This raises the...
7.
Aleyakpo B, Umukoro O, Kavlie R, Ranson D, Thompsett A, Corcoran O, et al.
Brain Neurosci Adv . 2020 Mar; 3:2398212819883081. PMID: 32166184
Ethanol is a psychoactive substance causing both short- and long-term behavioural changes in humans and animal models. We have used the fruit fly to investigate the effect of ethanol exposure...