Nathaniel J Moorman
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Explore the profile of Nathaniel J Moorman including associated specialties, affiliations and a list of published articles.
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90
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2162
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Recent Articles
1.
Dickmander R, Lenarcic E, Sears J, Hale A, Moorman N
Proc Natl Acad Sci U S A
. 2025 Mar;
122(10):e2421155122.
PMID: 40035757
Viruses have evolved unique strategies to circumvent host control of protein synthesis and enable viral protein synthesis in the face of the host response. Defining the factors that regulate viral...
2.
Ghoshal A, Tse E, Hossain M, Asressu K, Merten E, Sears J, et al.
Sci Rep
. 2025 Mar;
15(1):7264.
PMID: 40025188
Chikungunya is a mosquito-borne viral disease that causes fever and severe joint pain for which there is no direct acting drug treatments. Vinyl sulfone SGC-NSP2PRO-1 (3) was identified as a...
3.
Lenarcic E, Moorman N
bioRxiv
. 2025 Feb;
PMID: 39975304
Significance: Expression of the HCMV immediate early proteins IE1 and IE2 is critical for the establishment of lytic replication and the reactivation of latent HCMV infections. Defining the mechanisms controlling...
4.
Hossain M, Mayo A, Ghoshal A, Taft-Benz S, Anderson E, Morales N, et al.
bioRxiv
. 2025 Jan;
PMID: 39868137
RA-0002034 () is a potent covalent inhibitor targeting the alphavirus nsP2 cysteine protease. The species-dependent pharmacokinetics and metabolism of were investigated to evaluate its therapeutic potential. Pharmacokinetic profiling revealed rapid...
5.
Ghoshal A, Tse E, Hossain M, Asressu K, Merten E, Sears J, et al.
Res Sq
. 2024 Nov;
PMID: 39606462
RA-0003022 () was identified as a high-quality covalent chemical probe for nsP2 cysteine protease (nsP2pro). Isoxazole covalently captured the active site C478 and inactivated the enzyme with a / ratio...
6.
Topper M, Guarnieri J, Haltom J, Chadburn A, Cope H, Frere J, et al.
Proc Natl Acad Sci U S A
. 2024 Nov;
121(49):e2401968121.
PMID: 39602262
Lethal COVID-19 outcomes are attributed to classic cytokine storm. We revisit this using RNA sequencing of nasopharyngeal and 40 autopsy samples from patients dying of SARS-CoV-2. Subsets of the 100...
7.
Shirasaki T, Lenarcic E, Misumi I, Xie L, Fusco W, Yonish B, et al.
Sci Adv
. 2024 Nov;
10(47):eadq6342.
PMID: 39565848
The overexpression and misfolding of viral proteins in the endoplasmic reticulum (ER) may cause cellular stress, thereby inducing a cytoprotective, proteostatic host response involving phosphorylation of eukaryotic translation initiation factor...
8.
Lenarcic E, Hale A, Vincent H, Dickmander R, Sanders W, Moorman N
J Virol
. 2024 Oct;
98(11):e0059024.
PMID: 39470211
Human cytomegalovirus (HCMV) is a ubiquitous pathogen that infects the majority of the world's population. Lytic HCMV replication in immunocompromised individuals or neonates can lead to severe disease in multiple...
9.
Merten E, Sears J, Leisner T, Hardy P, Ghoshal A, Hossain M, et al.
Proc Natl Acad Sci U S A
. 2024 Oct;
121(42):e2409166121.
PMID: 39388272
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that has been responsible for numerous large-scale outbreaks in the last twenty years. Currently, there are no FDA-approved therapeutics for any alphavirus infection....
10.
Freeman M, Dooley A, Beucler M, Sanders W, Moorman N, OConnor C, et al.
bioRxiv
. 2024 Sep;
PMID: 39345593
Human cytomegalovirus (HCMV) is a β-herpesvirus which is ubiquitous in the human population. HCMV has the largest genome of all known human herpesviruses, and thus encodes a large array of...