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Wes Sanders

Explore the profile of Wes Sanders including associated specialties, affiliations and a list of published articles. Areas
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Articles 21
Citations 664
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Recent Articles
1.
Lenarcic E, Hale A, Vincent H, Dickmander R, Sanders W, Moorman N
J Virol . 2024 Oct; 98(11):e0059024. PMID: 39470211
Human cytomegalovirus (HCMV) is a ubiquitous pathogen that infects the majority of the world's population. Lytic HCMV replication in immunocompromised individuals or neonates can lead to severe disease in multiple...
2.
Freeman M, Dooley A, Beucler M, Sanders W, Moorman N, OConnor C, et al.
bioRxiv . 2024 Sep; PMID: 39345593
Human cytomegalovirus (HCMV) is a β-herpesvirus which is ubiquitous in the human population. HCMV has the largest genome of all known human herpesviruses, and thus encodes a large array of...
3.
Levi L, Madden E, Boussier J, Erazo D, Sanders W, Vallet T, et al.
Microorganisms . 2024 Sep; 12(9). PMID: 39338469
Chikungunya virus (CHIKV) is a mosquito-borne RNA virus that poses an emerging threat to humans. In a manner similar to other RNA viruses, CHIKV encodes an error-prone RNA polymerase which,...
4.
Ander S, Carpentier K, Sanders W, Lucas C, Jolly A, Johnson C, et al.
Viruses . 2024 Jun; 16(6). PMID: 38932154
We previously reported that deletion of a 44-nucleotide element in the 3' untranslated region (UTR) of the Chikungunya virus (CHIKV) genome enhances the virulence of CHIKV infection in mice. Here,...
5.
Diaz J, Sears J, Chang C, Burdick J, Law I, Sanders W, et al.
Viruses . 2024 Apr; 16(4). PMID: 38675976
RNA viruses quickly evolve subtle genotypic changes that can have major impacts on viral fitness and host range, with potential consequences for human health. It is therefore important to understand...
6.
Dickmander B, Hale A, Sanders W, Lenarcic E, Ziehr B, Moorman N
mBio . 2024 Jan; 15(2):e0262123. PMID: 38165154
Human cytomegalovirus (HCMV) requires the robust expression of two immediate early proteins, IE1 and IE2, immediately upon infection to suppress the antiviral response and promote viral gene expression. While transcriptional...
7.
Fritch E, Sanders W, Sims A, Herring L, Barker N, Schepmoes A, et al.
iScience . 2023 May; 26(6):106780. PMID: 37193127
Among all RNA viruses, coronavirus RNA transcription is the most complex and involves a process termed "discontinuous transcription" that results in the production of a set of 3'-nested, co-terminal genomic...
8.
Haese N, May N, Taft-Benz S, Moukha-Chafiq O, Madadi N, Zhang S, et al.
Antimicrob Agents Chemother . 2021 Jun; 65(9):e0024421. PMID: 34152810
Venezuelan equine encephalitis virus (VEEV) is a reemerging alphavirus that can cause encephalitis resulting in severe human morbidity and mortality. Using a high-throughput cell-based screen, we identified a quinolinone compound...
9.
Gravel A, Sanders W, Fournier E, Droit A, Moorman N, Flamand L
J Virol . 2021 Feb; 95(10). PMID: 33627386
The "omics" revolution of recent years has simplified the study of RNA transcripts produced during viral infection and under specific defined conditions. In the quest to find new and differentially...
10.
Leist S, Dinnon 3rd K, Schafer A, Tse L, Okuda K, Hou Y, et al.
Cell . 2020 Oct; 183(4):1070-1085.e12. PMID: 33031744
The SARS-CoV-2 pandemic has caused extreme human suffering and economic harm. We generated and characterized a new mouse-adapted SARS-CoV-2 virus that captures multiple aspects of severe COVID-19 disease in standard...