Nathaniel J Moorman
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Explore the profile of Nathaniel J Moorman including associated specialties, affiliations and a list of published articles.
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90
Citations
2162
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Recent Articles
11.
Levi L, Madden E, Boussier J, Erazo D, Sanders W, Vallet T, et al.
Microorganisms
. 2024 Sep;
12(9).
PMID: 39338469
Chikungunya virus (CHIKV) is a mosquito-borne RNA virus that poses an emerging threat to humans. In a manner similar to other RNA viruses, CHIKV encodes an error-prone RNA polymerase which,...
12.
Ong H, Yang X, Smith J, Taft-Benz S, Howell S, Dickmander R, et al.
Molecules
. 2024 Sep;
29(17).
PMID: 39275006
The host kinase casein kinase 2 (CSNK2) has been proposed to be an antiviral target against β-coronaviral infection. To pharmacologically validate CSNK2 as a drug target in vivo, potent and...
13.
Ghoshal A, Asressu K, Hossain M, Brown P, Nandakumar M, Vala A, et al.
J Med Chem
. 2024 Sep;
67(18):16505-16532.
PMID: 39235978
Despite their widespread impact on human health, there are no approved drugs for combating alphavirus infections. The heterocyclic β-aminomethyl vinyl sulfone RA-0002034 () is a potent irreversible covalent inhibitor of...
14.
Meganck R, Ogurlu R, Liu J, Moller-Tank S, Tse V, Blondel L, et al.
J Virol
. 2024 Jul;
98(8):e0009524.
PMID: 39082815
Importance: Viral RNA elements can hijack host cell machinery to control stability of transcripts and consequently, infection. Studies that help better understand such viral elements can provide insights into antiviral...
15.
Ong H, Yang X, Smith J, Dickmander R, Brown J, Havener T, et al.
J Med Chem
. 2024 Jul;
67(14):12261-12313.
PMID: 38959455
The pyrazolo[1,5-]pyrimidine scaffold is a promising scaffold to develop potent and selective CSNK2 inhibitors with antiviral activity against β-coronaviruses. Herein, we describe the discovery of a 1,2,4-triazole group to substitute...
16.
Ander S, Carpentier K, Sanders W, Lucas C, Jolly A, Johnson C, et al.
Viruses
. 2024 Jun;
16(6).
PMID: 38932154
We previously reported that deletion of a 44-nucleotide element in the 3' untranslated region (UTR) of the Chikungunya virus (CHIKV) genome enhances the virulence of CHIKV infection in mice. Here,...
17.
Ghoshal A, Asressu K, Hossain M, Brown P, Merten E, Sears J, et al.
bioRxiv
. 2024 Jun;
PMID: 38915519
Despite their widespread impact on human health there are no approved drugs for combating alphavirus infections. The heterocyclic β-aminomethyl vinyl sulfone RA-0002034 () is a potent irreversible covalent inhibitor of...
18.
Collins-McMillen D, De Oliveira Pessoa D, Zarrella K, Parkins C, Daily M, Moorman N, et al.
bioRxiv
. 2024 Jun;
PMID: 38826434
HCMV genes and play opposing roles regulating latency and reactivation in CD34 human progenitor cells (HPCs). Using the THP-1 cell line model for latency and reactivation, we designed an RNA...
19.
Genito C, Darwitz B, Reber C, Moorman N, Graves C, Monteith A, et al.
mBio
. 2024 May;
15(6):e0086224.
PMID: 38767353
Mammalian target of rapamycin (mTOR) is a key regulator of metabolism in the mammalian cell. Here, we show the essential role for mTOR signaling in the immune response to bacterial...
20.
Merten E, Sears J, Leisner T, Hardy P, Ghoshal A, Hossain M, et al.
bioRxiv
. 2024 Apr;
PMID: 38562906
Significance Statement: Chikungunya virus is one of the most prominent and widespread alphaviruses and has caused explosive outbreaks of arthritic disease. Currently, there are no FDA-approved drugs to treat disease...