Natalia Zelinskaya
Overview
Explore the profile of Natalia Zelinskaya including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
12
Citations
127
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Srinivas P, Nosrati M, Zelinskaya N, Dey D, Comstock L, Dunham C, et al.
Proc Natl Acad Sci U S A
. 2023 Jun;
120(25):e2304128120.
PMID: 37307464
Acquired ribosomal RNA (rRNA) methylation has emerged as a significant mechanism of aminoglycoside resistance in pathogenic bacterial infections. Modification of a single nucleotide in the ribosome decoding center by the...
2.
Srinivas P, Nosrati M, Zelinskaya N, Dey D, Comstock L, Dunham C, et al.
bioRxiv
. 2023 Mar;
PMID: 36993224
Acquired ribosomal RNA (rRNA) methylation has emerged as a significant mechanism of aminoglycoside resistance in pathogenic bacterial infections. Modification of a single nucleotide in the ribosome decoding center by the...
3.
Laughlin Z, Nandi S, Dey D, Zelinskaya N, Witek M, Srinivas P, et al.
Proc Natl Acad Sci U S A
. 2022 Mar;
119(14):e2120352119.
PMID: 35357969
Changes in bacterial ribosomal RNA (rRNA) methylation status can alter the activity of diverse groups of ribosome-targeting antibiotics. These modifications are typically incorporated by a single methyltransferase that acts on...
4.
Nosrati M, Dey D, Mehrani A, Strassler S, Zelinskaya N, Hoffer E, et al.
J Biol Chem
. 2019 Oct;
294(46):17642-17653.
PMID: 31594862
Methylation of the small ribosome subunit rRNA in the ribosomal decoding center results in exceptionally high-level aminoglycoside resistance in bacteria. Enzymes that methylate 16S rRNA on N7 of nucleotide G1405...
5.
Owings J, Kuiper E, Prezioso S, Meisner J, Varga J, Zelinskaya N, et al.
J Biol Chem
. 2015 Dec;
291(7):3280-90.
PMID: 26677219
Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen that trimethylates elongation factor-thermo-unstable (EF-Tu) on lysine 5. Lysine 5 methylation occurs in a temperature-dependent manner and is generally only seen when P....
6.
Correa L, Witek M, Zelinskaya N, Picao R, Conn G
Antimicrob Agents Chemother
. 2015 Nov;
60(1):699-702.
PMID: 26552988
The exogenously acquired 16S rRNA methyltransferases RmtD, RmtD2, and RmtG were cloned and heterologously expressed in Escherichia coli, and the recombinant proteins were purified to near homogeneity. Each methyltransferase conferred...
7.
Zelinskaya N, Witek M, Conn G
Antimicrob Agents Chemother
. 2015 Sep;
59(12):7862-5.
PMID: 26416864
Chemical modification of 16S rRNA can confer exceptionally high-level resistance to a diverse set of aminoglycoside antibiotics. Here, we show that the pathogen-derived enzyme NpmA possesses dual m(1)A1408/m(1)G1408 activity, an...
8.
Savic M, Sunita S, Zelinskaya N, Desai P, Macmaster R, Vinal K, et al.
Antimicrob Agents Chemother
. 2015 Mar;
59(5):2807-16.
PMID: 25733511
Methylation of bacterial 16S rRNA within the ribosomal decoding center confers exceptionally high resistance to aminoglycoside antibiotics. This resistance mechanism is exploited by aminoglycoside producers for self-protection while functionally equivalent...
9.
Dunkle J, Vinal K, Desai P, Zelinskaya N, Savic M, West D, et al.
Proc Natl Acad Sci U S A
. 2014 Apr;
111(17):6275-80.
PMID: 24717845
Aminoglycosides are potent, broad spectrum, ribosome-targeting antibacterials whose clinical efficacy is seriously threatened by multiple resistance mechanisms. Here, we report the structural basis for 30S recognition by the novel plasmid-mediated...
10.
Stolboushkina E, Nikonov S, Zelinskaya N, Arkhipova V, Nikulin A, Garber M, et al.
J Mol Biol
. 2013 Jan;
425(6):989-98.
PMID: 23291527
Heterotrimeric aIF2αβγ (archaeal homologue of the eukaryotic translation initiation factor 2) in its GTP-bound form delivers Met-tRNAi(Met) to the small ribosomal subunit. It is known that the heterodimer containing the...