The Pathogen-Derived Aminoglycoside Resistance 16S RRNA Methyltransferase NpmA Possesses Dual M1A1408/m1G1408 Specificity

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2015 Sep 30

PMID 26416864

Citations 4

Authors

Natalia Zelinskaya

Marta A Witek

Graeme L Conn

Affiliations

Soon will be listed here.

Abstract

Chemical modification of 16S rRNA can confer exceptionally high-level resistance to a diverse set of aminoglycoside antibiotics. Here, we show that the pathogen-derived enzyme NpmA possesses dual m(1)A1408/m(1)G1408 activity, an unexpected property apparently unique among the known aminoglycoside resistance 16S rRNA (m(1)A1408) methyltransferases. Although the biological significance of this activity remains to be determined, such mechanistic variation in enzymes acquired by pathogens has significant implications for development of inhibitors of these emerging resistance determinants.

Citing Articles

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