Nancy C Horton
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Explore the profile of Nancy C Horton including associated specialties, affiliations and a list of published articles.
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34
Citations
389
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Recent Articles
1.
Horton N, Lyumkis D
Crit Rev Biochem Mol Biol
. 2024 Dec;
:1-39.
PMID: 39699272
This review documents investigations leading to the unprecedented discovery of filamentation as a mode of enzyme regulation in the type II restriction endonuclease SgrAI. Filamentation is defined here as linear...
2.
Shan Z, Rivero-Gamez A, Lyumkis D, Horton N
J Biol Chem
. 2024 Jul;
300(8):107576.
PMID: 39009341
Enzymes that form filamentous assemblies with modulated enzymatic activities have gained increasing attention in recent years. SgrAI is a sequence specific type II restriction endonuclease that forms polymeric filaments with...
3.
Ghadirian N, Morgan R, Horton N
Biochemistry
. 2024 Jan;
63(3):326-338.
PMID: 38207281
Enzyme polymerization (also known as filamentation) has emerged as a new layer of enzyme regulation. SgrAI is a sequence-dependent DNA endonuclease that forms polymeric filaments with enhanced DNA cleavage activity...
4.
Zerio C, Sivinski J, Wijeratne E, Xu Y, Ngo D, Ambrose A, et al.
J Med Chem
. 2022 Dec;
66(1):913-933.
PMID: 36577036
A pulldown using a biotinylated natural product of interest in the 17β-hydroxywithanolide (17-BHW) class, physachenolide C (PCC), identified the bromodomain and extra-terminal domain (BET) family of proteins (BRD2, BRD3, and...
5.
Lyumkis D, Horton N
Biochem Soc Trans
. 2022 Nov;
50(6):1703-1714.
PMID: 36398769
Filament formation by metabolic, biosynthetic, and other enzymes has recently come into focus as a mechanism to fine-tune enzyme activity in the cell. Filamentation is key to the function of...
6.
Sanchez J, Ghadirian N, Horton N
J Virol
. 2022 Apr;
96(9):e0216421.
PMID: 35435730
Two new structures of the N-terminal domain of the main replication protein, NS1, of human parvovirus B19 (B19V) are presented here. This domain (NS1-nuc) plays an important role in the...
7.
Shan Z, Ghadirian N, Lyumkis D, Horton N
J Biol Chem
. 2022 Feb;
298(4):101760.
PMID: 35202658
Enzyme filamentation is a widespread phenomenon that mediates enzyme regulation and function. For the filament-forming sequence-specific DNA endonuclease SgrAI, the process of filamentation both accelerates its DNA cleavage activity and...
8.
Townsend J, Sanders H, Rolland A, Park C, Horton N, Prell J, et al.
Anal Chem
. 2021 Nov;
93(48):16273-16281.
PMID: 34813702
Viroporins are small viral ion channels that play important roles in the viral infection cycle and are proven antiviral drug targets. Matrix protein 2 from influenza A (AM2) is the...
9.
Park C, Horton N
Biophys Rev
. 2019 Nov;
11(6):927-994.
PMID: 31734826
Filament formation by non-cytoskeletal enzymes has been known for decades, yet only relatively recently has its wide-spread role in enzyme regulation and biology come to be appreciated. This comprehensive review...
10.