Carlos F Barbas 3rd
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Explore the profile of Carlos F Barbas 3rd including associated specialties, affiliations and a list of published articles.
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178
Citations
6300
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Recent Articles
1.
Perdigao P, Cunha-Santos C, Barbas 3rd C, Santa-Marta M, Goncalves J
Mol Ther Methods Clin Dev
. 2020 Jul;
18:145-158.
PMID: 32637446
Despite efforts to develop effective treatments for eradicating HIV-1, a cure has not yet been achieved. Whereas antiretroviral drugs target an actively replicating virus, latent, nonreplicative forms persist during treatment....
2.
Nagano M, Carrillo N, Otsubo N, Hakamata W, Ban H, Fuller R, et al.
Bioorg Med Chem
. 2017 Oct;
25(21):5952-5961.
PMID: 28988625
Vaccination is a reliable method of prophylaxis and a crucial measure for public health. However, the majority of vaccines cannot be administered orally due to their degradation in the harsh...
3.
Patterson J, Wilson H, Asano S, Nilchan N, Fuller R, Roush W, et al.
Bioconjug Chem
. 2016 Sep;
27(10):2271-2275.
PMID: 27666414
Bioorthogonal labeling of antibodies enables the conjugation of compounds, such as small molecules or peptides, which expand targeting capacity or enhance cytotoxicity. Taking advantage of a cyclohexene sulfonamide compound that...
4.
Perdigao P, Gaj T, Santa-Marta M, Barbas 3rd C, Goncalves J
PLoS One
. 2016 Mar;
11(3):e0150037.
PMID: 26933881
The presence of replication-competent HIV-1 -which resides mainly in resting CD4+ T cells--is a major hurdle to its eradication. While pharmacological approaches have been useful for inducing the expression of...
5.
Liu J, Gaj T, Yang Y, Wang N, Shui S, Kim S, et al.
Nat Protoc
. 2015 Oct;
10(11):1842-59.
PMID: 26492140
Targeted nucleases, including zinc-finger nucleases (ZFNs), transcription activator-like (TAL) effector nucleases (TALENs) and clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein 9 (Cas9), have provided researchers with the ability to...
6.
Wallen M, Gaj T, Barbas 3rd C
PLoS One
. 2015 Sep;
10(9):e0139123.
PMID: 26414179
Site-specific recombinases (SSRs) are valuable tools for genetic engineering due to their ability to manipulate DNA in a highly specific manner. Engineered zinc-finger and TAL effector recombinases, in particular, are...
7.
Inokuma T, Fuller R, Barbas 3rd C
Bioorg Med Chem Lett
. 2015 Mar;
25(8):1684-1687.
PMID: 25791455
Utilization of chemically programmed antibodies (cpAbs) is regarded to be one of the most efficient methods for the development of therapeutic systems. cpAbs can extend the half-life of programming reagents,...
8.
Liu J, Gaj T, Wallen M, Barbas 3rd C
Mol Ther Nucleic Acids
. 2015 Mar;
4:e232.
PMID: 25756962
Safe, efficient, and broadly applicable methods for delivering site-specific nucleases into cells are needed in order for targeted genome editing to reach its full potential for basic research and medicine....
9.
Lamb B, Barbas 3rd C
Chem Commun (Camb)
. 2015 Jan;
51(15):3196-9.
PMID: 25604598
A routine thioketal protecting group reacts rapidly and selectively with singlet oxygen to reveal ketone products in good (aryl 1,3-dithiolane) to excellent (aryl 1,3-oxathiolane) yields. Arylthiolanes are stable to biologically...
10.
Gaj T, Barbas 3rd C
Methods Enzymol
. 2014 Nov;
546:79-91.
PMID: 25398336
Site-specific recombinases are valuable tools for myriad basic research and genome engineering applications. In particular, hybrid recombinases consisting of catalytic domains from the resolvase/invertase family of serine recombinases fused to...