Nancy C Hancock
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Explore the profile of Nancy C Hancock including associated specialties, affiliations and a list of published articles.
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10
Citations
194
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Recent Articles
1.
Ishii K, Hermans S, Georgopoulou M, Nero T, Hancock N, Crespi G, et al.
FEBS J
. 2024 Sep;
291(24):5398-5419.
PMID: 39325669
Human 5'-3' exonuclease PLD3, a member of the phospholipase D family of enzymes, has been validated as a therapeutic target for treating Alzheimer's disease. Here, we have determined the crystal...
2.
Hermans S, Nero T, Morton C, Gooi J, Crespi G, Hancock N, et al.
Biophys Rev
. 2022 Mar;
14(1):233-255.
PMID: 35340615
Alzheimer's disease is a common and devastating age-related disease with no effective disease-modifying treatments. Human genetics has implicated a wide range of cell surface receptors as playing a role in...
3.
Wong S, Vivash L, Mudududdla R, Nguyen N, Hermans S, Shackleford D, et al.
Eur J Med Chem
. 2021 Sep;
226:113822.
PMID: 34563964
MER tyrosine kinase (MERTK) upregulation is associated with M2 polarization of microglia, which plays a vital role in neuroregeneration following damage induced by neuroinflammatory diseases such as multiple sclerosis (MS)....
4.
Miles L, Hermans S, Crespi G, Gooi J, Doughty L, Nero T, et al.
iScience
. 2019 Aug;
19:110-118.
PMID: 31369984
Polymorphism in the microglial receptor CD33 gene has been linked to late-onset Alzheimer disease (AD), and reduced expression of the CD33 sialic acid-binding domain confers protection. Thus, CD33 inhibition might...
5.
De Luca A, Parker L, Ang W, Rodolfo C, Gabbarini V, Hancock N, et al.
Proc Natl Acad Sci U S A
. 2019 Jun;
116(28):13943-13951.
PMID: 31221747
Cisplatin [diamminedichloroplatinum(II) (-DDP)] is one of the most successful anticancer agents effective against a wide range of solid tumors. However, its use is restricted by side effects and/or by intrinsic...
6.
Hermans S, Ascher D, Hancock N, Holien J, Michell B, Chai S, et al.
Protein Sci
. 2014 Nov;
24(2):190-9.
PMID: 25408552
Insulin-regulated aminopeptidase (IRAP or oxytocinase) is a membrane-bound zinc-metallopeptidase that cleaves neuroactive peptides in the brain and produces memory enhancing effects when inhibited. We have determined the crystal structure of...
7.
Nankervis J, Feil S, Hancock N, Zheng Z, Ng H, Morton C, et al.
Bioorg Med Chem Lett
. 2011 Oct;
21(23):7089-93.
PMID: 22030030
PDE4 inhibitors have been identified as therapeutic targets for a variety of conditions, particularly inflammatory diseases. We have serendipitously identified a novel class of phosphodiesterase 4 (PDE4) inhibitor during a...
8.
Parker L, Italiano L, Morton C, Hancock N, Ascher D, Aitken J, et al.
Chemistry
. 2011 Jun;
17(28):7806-16.
PMID: 21681839
Platinum-based cancer drugs, such as cisplatin, are highly effective chemotherapeutic agents used extensively for the treatment of solid tumors. However, their effectiveness is limited by drug resistance, which, in some...
9.
Parker L, Ciccone S, Italiano L, Primavera A, Oakley A, Morton C, et al.
J Mol Biol
. 2008 May;
380(1):131-44.
PMID: 18511072
The commonly used anti-cancer drug chlorambucil is the primary treatment for patients with chronic lymphocytic leukaemia. Chlorambucil has been shown to be detoxified by human glutathione transferase Pi (GST P1-1),...
10.
House C, Hancock N, Moller A, Cromer B, Fedorov V, Bowtell D, et al.
Structure
. 2006 Apr;
14(4):695-701.
PMID: 16615911
The Siah family of RING proteins function as ubiquitin ligase components, contributing to the degradation of multiple targets involved in cell growth, differentiation, angiogenesis, oncogenesis, and inflammation. Previously, a binding...