Craig J Morton
Overview
Explore the profile of Craig J Morton including associated specialties, affiliations and a list of published articles.
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80
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1841
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Recent Articles
1.
Amarasinghe P, Allison L, Morton C, Stuckey P, Garcia de la Banda M, Lesk A, et al.
Proc Natl Acad Sci U S A
. 2025 Jan;
122(1):e2416301121.
PMID: 39746043
As structural biology and drug discovery depend on high-quality protein structures, assessment tools are essential. We describe a new method for validating amino-acid conformations: "PhiSiCal ([Formula: see text]al) Checkup." Twenty...
2.
Xie S, Tai C, Morton C, Ma L, Huang S, Wittlin S, et al.
PLoS Pathog
. 2024 Dec;
20(12):e1012429.
PMID: 39652589
The Plasmodium falciparum cytoplasmic tyrosine tRNA synthetase (PfTyrRS) is an attractive drug target that is susceptible to reaction-hijacking by AMP-mimicking nucleoside sulfamates. We previously identified an exemplar pyrazolopyrimidine ribose sulfamate,...
3.
Zeller J, Loseff-Silver J, Khoshmanesh K, Baratchi S, Lai A, Nero T, et al.
Circ Res
. 2024 Oct;
135(11):1033-1047.
PMID: 39421928
Background: CRP (C-reactive protein) is a prototypical acute phase reactant. Upon dissociation of the pentameric isoform (pCRP [pentameric CRP]) into its monomeric subunits (mCRP [monomeric CRP]), it exhibits prothrombotic and...
4.
Abrahamsen H, Sanford T, Collamore C, Johnstone B, Coyne M, Garcia-Bayona L, et al.
Nat Commun
. 2024 Jun;
15(1):5028.
PMID: 38866748
Cholesterol-dependent cytolysins (CDCs) comprise a large family of pore-forming toxins produced by Gram-positive bacteria, which are used to attack eukaryotic cells. Here, we functionally characterize a family of 2-component CDC-like...
5.
Xie S, Wang Y, Morton C, Metcalfe R, Dogovski C, Pasaje C, et al.
Nat Commun
. 2024 Jan;
15(1):937.
PMID: 38297033
Malaria poses an enormous threat to human health. With ever increasing resistance to currently deployed drugs, breakthrough compounds with novel mechanisms of action are urgently needed. Here, we explore pyrimidine-based...
6.
Metcalfe R, Hanssen E, Fung K, Aizel K, Kosasih C, Zlatic C, et al.
Nat Commun
. 2023 Nov;
14(1):7543.
PMID: 37985757
Interleukin (IL-)11, an IL-6 family cytokine, has pivotal roles in autoimmune diseases, fibrotic complications, and solid cancers. Despite intense therapeutic targeting efforts, structural understanding of IL-11 signalling and mechanistic insights...
7.
Xie S, Wang Y, Morton C, Metcalfe R, Dogovski C, Pasaje C, et al.
Res Sq
. 2023 Aug;
PMID: 37546892
Malaria poses an enormous threat to human health. With ever increasing resistance to currently deployed drugs, breakthrough compounds with novel mechanisms of action are urgently needed. Here, we explore pyrimidine-based...
8.
Lee L, Suryadinata R, McCafferty C, Ignjatovic V, Purcell D, Robinson P, et al.
Viruses
. 2022 Dec;
14(12).
PMID: 36560624
SARS-CoV-2 is the causative agent of the COVID-19 pandemic. Vaccination, supported by social and public health measures, has proven efficacious for reducing disease severity and virus spread. However, the emergence...
9.
Zeller J, Cheung Tung Shing K, Nero T, McFadyen J, Krippner G, Bogner B, et al.
EMBO Mol Med
. 2022 Dec;
15(1):e16236.
PMID: 36468184
C-reactive protein (CRP) is an early-stage acute phase protein and highly upregulated in response to inflammatory reactions. We recently identified a novel mechanism that leads to a conformational change from...
10.
Dix C, Zeller J, Stevens H, Eisenhardt S, Cheung Tung Shing K, Nero T, et al.
Front Immunol
. 2022 Sep;
13:1002652.
PMID: 36177015
C-reactive protein (CRP) is a member of the highly conserved pentraxin superfamily of proteins and is often used in clinical practice as a marker of infection and inflammation. There is...