Jonathan H Gooi
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Explore the profile of Jonathan H Gooi including associated specialties, affiliations and a list of published articles.
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30
Citations
1086
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Recent Articles
1.
Ishii K, Hermans S, Georgopoulou M, Nero T, Hancock N, Crespi G, et al.
FEBS J
. 2024 Sep;
291(24):5398-5419.
PMID: 39325669
Human 5'-3' exonuclease PLD3, a member of the phospholipase D family of enzymes, has been validated as a therapeutic target for treating Alzheimer's disease. Here, we have determined the crystal...
2.
Wee N, McGregor N, Walker E, Poulton I, Dang M, Gooi J, et al.
J Bone Miner Res
. 2024 Jul;
39(8):1174-1187.
PMID: 38959852
Intracellular phosphoinositide 3-kinase (PI3K) signaling is activated by multiple bone-active receptors. Genetic mutations activating PI3K signaling are associated with clinical syndromes of tissue overgrowth in multiple organs, often including the...
3.
Isojima T, Walker E, Poulton I, McGregor N, Wicks I, Gooi J, et al.
J Bone Miner Res
. 2022 Jul;
37(10):1876-1890.
PMID: 35856245
Bone strength is determined by the structure and composition of its thickened outer shell (cortical bone), yet the mechanisms controlling cortical consolidation are poorly understood. Cortical bone maturation depends on...
4.
Blank M, McGregor N, Rowley L, Kung L, Crimeen-Irwin B, Poulton I, et al.
J Cell Mol Med
. 2022 Jun;
26(14):4021-4031.
PMID: 35701367
The inherited brittle bone disease osteogenesis imperfecta (OI) is commonly caused by COL1A1 and COL1A2 mutations that disrupt the collagen I triple helix. This causes intracellular endoplasmic reticulum (ER) retention...
5.
Hermans S, Nero T, Morton C, Gooi J, Crespi G, Hancock N, et al.
Biophys Rev
. 2022 Mar;
14(1):233-255.
PMID: 35340615
Alzheimer's disease is a common and devastating age-related disease with no effective disease-modifying treatments. Human genetics has implicated a wide range of cell surface receptors as playing a role in...
6.
Al Saedi A, Sharma S, Bani Hassan E, Chen L, Ghasem-Zadeh A, Hassanzadeganroudsari M, et al.
Inflamm Bowel Dis
. 2021 Aug;
28(2):259-272.
PMID: 34347076
Background: Osteoporosis is a common extraintestinal manifestation of inflammatory bowel disease (IBD). However, studies have been scarce, mainly because of the lack of an appropriate animal model of colitis-associated bone...
7.
Ansari N, Isojima T, Crimeen-Irwin B, Poulton I, McGregor N, Ho P, et al.
J Bone Miner Res
. 2021 Jun;
36(10):1999-2016.
PMID: 34101894
Parathyroid hormone-related protein (PTHrP, gene name Pthlh) is a pleiotropic regulator of tissue homeostasis. In bone, Dmp1Cre-targeted PTHrP deletion in osteocytes causes osteopenia and impaired cortical strength. We report here...
8.
Walker E, Truong K, McGregor N, Poulton I, Isojima T, Gooi J, et al.
Elife
. 2020 May;
9.
PMID: 32458800
Bone strength is determined by its dense cortical shell, generated by unknown mechanisms. Here we use the mouse, with delayed cortical bone consolidation, to characterise cortical maturation and identify control...
9.
Miles L, Hermans S, Crespi G, Gooi J, Doughty L, Nero T, et al.
iScience
. 2019 Aug;
19:110-118.
PMID: 31369984
Polymorphism in the microglial receptor CD33 gene has been linked to late-onset Alzheimer disease (AD), and reduced expression of the CD33 sialic acid-binding domain confers protection. Thus, CD33 inhibition might...
10.
McGregor N, Murat M, Elango J, Poulton I, Walker E, Crimeen-Irwin B, et al.
J Biol Chem
. 2019 Mar;
294(19):7850-7863.
PMID: 30923130
Interleukin 6 (IL-6) supports development of bone-resorbing osteoclasts by acting early in the osteoblast lineage via membrane-bound () or soluble () receptors. Here, we investigated how IL-6 signals and modifies...