Najeah Okashah
Overview
Explore the profile of Najeah Okashah including associated specialties, affiliations and a list of published articles.
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9
Citations
342
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0
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Recent Articles
1.
Okashah N, Wright S, Kawakami K, Mathiasen S, Zhou J, Lu S, et al.
Proc Natl Acad Sci U S A
. 2020 Aug;
117(35):21723-21730.
PMID: 32817560
G proteins are activated when they associate with G protein-coupled receptors (GPCRs), often in response to agonist-mediated receptor activation. It is generally thought that agonist-induced receptor-G protein association necessarily promotes...
2.
Mathiasen S, Palmisano T, Perry N, Stoveken H, Vizurraga A, McEwen D, et al.
Nat Chem Biol
. 2020 Aug;
16(12):1440.
PMID: 32807971
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
3.
Mathiasen S, Palmisano T, Perry N, Stoveken H, Vizurraga A, McEwen D, et al.
Nat Chem Biol
. 2020 Aug;
16(12):1343-1350.
PMID: 32778842
The adhesion G-protein-coupled receptor (GPCR) latrophilin 3 (ADGRL3) has been associated with increased risk of attention deficit hyperactivity disorder (ADHD) and substance use in human genetic studies. Knockdown in multiple...
4.
Pritchard A, Kanai S, Krock B, Schindewolf E, Oliver-Krasinski J, Khalek N, et al.
Am J Med Genet A
. 2020 Mar;
182(5):1104-1116.
PMID: 32133772
Craniofacial morphogenesis is regulated in part by signaling from the Endothelin receptor type A (EDNRA). Pathogenic variants in EDNRA signaling pathway components EDNRA, GNAI3, PCLB4, and EDN1 cause Mandibulofacial Dysostosis...
5.
Okashah N, Wan Q, Ghosh S, Sandhu M, Inoue A, Vaidehi N, et al.
Proc Natl Acad Sci U S A
. 2019 May;
116(24):12054-12059.
PMID: 31142646
G protein-coupled receptors (GPCRs) activate four families of heterotrimeric G proteins, and individual receptors must select a subset of G proteins to produce appropriate cellular responses. Although the precise mechanisms...
6.
Wright S, Kozielewicz P, Kowalski-Jahn M, Petersen J, Bowin C, Slodkowicz G, et al.
Nat Commun
. 2019 Feb;
10(1):667.
PMID: 30737406
Class F receptors are considered valuable therapeutic targets due to their role in human disease, but structural changes accompanying receptor activation remain unexplored. Employing population and cancer genomics data, structural...
7.
Wan Q, Okashah N, Inoue A, Nehme R, Carpenter B, Tate C, et al.
J Biol Chem
. 2018 Mar;
293(19):7466-7473.
PMID: 29523687
G protein-coupled receptors (GPCRs) are key signaling proteins that regulate nearly every aspect of cell function. Studies of GPCRs have benefited greatly from the development of molecular tools to monitor...
8.
White S, Alva-Ruiz R, Chen L, Conger J, Kuang C, Murphy C, et al.
J Ga Public Health Assoc
. 2017 Jan;
6(2):331-336.
PMID: 28066831
Background: Diet-related chronic diseases, such as diabetes mellitus, hypertension, and hyperlipidemia have affected millions of individuals, resulting in disease-related complications and mortality. Strategies that may improve the outcome of chronic...
9.
Barsoum D, Okashah N, Zhang X, Zhu L
J Org Chem
. 2015 Sep;
80(19):9542-51.
PMID: 26352108
5-Iodo-1,2,3-triazole (iodotriazole) can be prepared from a copper(I)-catalyzed reaction between azide and terminal alkyne in the presence of an iodinating agent, with 5-protio-1,2,3-triazole (protiotriazole) as the side product. The increasing...