Jonathan A Javitch
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Explore the profile of Jonathan A Javitch including associated specialties, affiliations and a list of published articles.
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Articles
225
Citations
10978
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Recent Articles
1.
Perry-Hauser N, Du Rand J, Lee K, Shi L, Javitch J
J Biol Chem
. 2025 Jan;
301(2):108174.
PMID: 39798870
Most adhesion G protein-coupled receptors (GPCRs) undergo autoproteolytic cleavage during receptor biosynthesis, resulting in noncovalently bound N-terminal fragments (NTFs) and C-terminal fragments (CTFs) that remain associated during receptor trafficking to...
2.
Lin X, Provasi D, Niswender C, Asher W, Javitch J
Nat Commun
. 2024 Oct;
15(1):8552.
PMID: 39362861
Metabotropic glutamate (mGlu) receptor protomers can heterodimerize, leading to different pharmacology compared to their homodimeric counterparts. Here, we use complemented donor-acceptor resonance energy transfer (CODA-RET) technology that distinguishes signaling from...
3.
Havel V, Kruegel A, Bechand B, McIntosh S, Stallings L, Hodges A, et al.
Nat Commun
. 2024 Sep;
15(1):8118.
PMID: 39304653
Ibogaine and its main metabolite noribogaine provide important molecular prototypes for markedly different treatment of substance use disorders and co-morbid mental health illnesses. However, these compounds present a cardiac safety...
4.
Zuo H, Park J, Frangaj A, Ye J, Lu G, Manning J, et al.
Nature
. 2024 Apr;
629(8011):481-488.
PMID: 38632411
The human calcium-sensing receptor (CaSR) detects fluctuations in the extracellular Ca concentration and maintains Ca homeostasis. It also mediates diverse cellular processes not associated with Ca balance. The functional pleiotropy...
5.
Lee W, Westergaard X, Hwu C, Hwu J, Fiala T, Lacefield C, et al.
J Am Chem Soc
. 2024 Apr;
146(14):9564-9574.
PMID: 38557024
The serotonergic transmitter system plays fundamental roles in the nervous system in neurotransmission, synaptic plasticity, pathological processes, and therapeutic effects of antidepressants and psychedelics, as well as in the gastrointestinal...
6.
Tsai M, Chen L, Baumann M, Canals M, Javitch J, Lane J, et al.
ACS Chem Neurosci
. 2024 Feb;
15(4):854-867.
PMID: 38345920
Novel synthetic opioids (NSOs), including both fentanyl and non-fentanyl analogs that act as μ-opioid receptor (MOR) agonists, are associated with serious intoxication and fatal overdose. Previous studies proposed that G-protein-biased...
7.
Filizola M, Javitch J
Science
. 2023 Dec;
382(6677):1357-1358.
PMID: 38127769
Advancing drug discovery requires increasingly integrative structural biology approaches.
8.
Tsai M, Chen L, Baumann M, Canals M, Javitch J, Lane J, et al.
bioRxiv
. 2023 Nov;
PMID: 38014284
Novel synthetic opioids (NSOs), including both fentanyl and non-fentanyl analogs that act as the μ-opioid receptor (MOR) agonists, are associated with serious intoxication and fatal overdose. Previous studies proposed that...
9.
Zheng C, Javitch J, Lambert N, Donthamsetti P, Gurevich V
Curr Protoc
. 2023 Oct;
3(10):e890.
PMID: 37787634
G protein-coupled receptors (GPCRs) represent ∼30% of current drug targets. Ligand binding to these receptors activates G proteins and arrestins, which function in different signaling pathways. Given that functionally selective...
10.
Chancey J, Kellendonk C, Javitch J, Lovinger D
bioRxiv
. 2023 Sep;
PMID: 37693570
Learning action sequences is necessary for normal daily activities. Medium spiny neurons (MSNs) in the dorsal striatum (dStr) encode action sequences through changes in firing at the start and/or stop...