Signe Mathiasen
Overview
Explore the profile of Signe Mathiasen including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
518
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0
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Recent Articles
1.
Kizilkaya H, Sorensen K, Madsen J, Lindquist P, Douros J, Bork-Jensen J, et al.
Nat Metab
. 2024 Jun;
6(7):1268-1281.
PMID: 38871982
Incretin-based therapies are highly successful in combatting obesity and type 2 diabetes. Yet both activation and inhibition of the glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) in combination with glucagon-like peptide-1...
2.
Rosenkilde M, Mathiasen S
Basic Clin Pharmacol Toxicol
. 2023 Aug;
133(4):281-285.
PMID: 37635311
No abstract available.
3.
Faas F, Norskov A, Holst P, Andersson A, Qvortrup K, Mathiasen S, et al.
Basic Clin Pharmacol Toxicol
. 2023 Aug;
133(4):378-389.
PMID: 37621135
Adhesion G protein-coupled receptors (aGPCRs) constitute the second largest subclass of the GPCR superfamily. Although canonical GPCRs are explored pharmacologically as drug targets, no clinically approved drugs target the aGPCR...
4.
Asher W, Geggier P, Holsey M, Gilmore G, Pati A, Meszaros J, et al.
Nat Methods
. 2021 Mar;
18(4):397-405.
PMID: 33686301
Class C G protein-coupled receptors (GPCRs) are known to form stable homodimers or heterodimers critical for function, but the oligomeric status of class A and B receptors, which constitute >90%...
5.
Novel Fluorescent Ligands Enable Single-Molecule Localization Microscopy of the Dopamine Transporter
Guthrie D, Klein Herenbrink C, Lycas M, Ku T, Bonifazi A, DeVree B, et al.
ACS Chem Neurosci
. 2020 Sep;
11(20):3288-3300.
PMID: 32926777
The dopamine transporter (DAT) is critical for spatiotemporal control of dopaminergic neurotransmission and is the target for therapeutic agents, including ADHD medications, and abused substances, such as cocaine. Here, we...
6.
Okashah N, Wright S, Kawakami K, Mathiasen S, Zhou J, Lu S, et al.
Proc Natl Acad Sci U S A
. 2020 Aug;
117(35):21723-21730.
PMID: 32817560
G proteins are activated when they associate with G protein-coupled receptors (GPCRs), often in response to agonist-mediated receptor activation. It is generally thought that agonist-induced receptor-G protein association necessarily promotes...
7.
Mathiasen S, Palmisano T, Perry N, Stoveken H, Vizurraga A, McEwen D, et al.
Nat Chem Biol
. 2020 Aug;
16(12):1440.
PMID: 32807971
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
8.
Mathiasen S, Palmisano T, Perry N, Stoveken H, Vizurraga A, McEwen D, et al.
Nat Chem Biol
. 2020 Aug;
16(12):1343-1350.
PMID: 32778842
The adhesion G-protein-coupled receptor (GPCR) latrophilin 3 (ADGRL3) has been associated with increased risk of attention deficit hyperactivity disorder (ADHD) and substance use in human genetic studies. Knockdown in multiple...
9.
Single Proteoliposome High-Content Analysis Reveals Differences in the Homo-Oligomerization of GPCRs
Walsh S, Mathiasen S, Christensen S, Fay J, King C, Provasi D, et al.
Biophys J
. 2018 Jul;
115(2):300-312.
PMID: 30021106
G-protein-coupled receptors (GPCRs) control vital cellular signaling pathways. GPCR oligomerization is proposed to increase signaling diversity. However, many reports have arrived at disparate conclusions regarding the existence, stability, and stoichiometry...
10.
Gregorio G, Masureel M, Hilger D, Terry D, Juette M, Zhao H, et al.
Nature
. 2017 Jun;
547(7661):68-73.
PMID: 28607487
G-protein-coupled receptor (GPCR)-mediated signal transduction is central to human physiology and disease intervention, yet the molecular mechanisms responsible for ligand-dependent signalling responses remain poorly understood. In class A GPCRs, receptor...