N Tony Eissa
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Explore the profile of N Tony Eissa including associated specialties, affiliations and a list of published articles.
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59
Citations
9957
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Recent Articles
11.
Li L, Mok H, Jhaveri P, Bonnen M, Sikora A, Eissa N, et al.
Expert Rev Anticancer Ther
. 2018 Jul;
18(10):1041-1057.
PMID: 29996062
Chemotherapy and radiation therapy are two mainstream strategies applied in the treatment of cancer that is not operable. Patients with hematological or solid tumor malignancies substantially benefit from chemotherapeutic drugs...
12.
Yao C, Veleva T, Scott Jr L, Cao S, Li L, Chen G, et al.
Circulation
. 2018 May;
138(20):2227-2242.
PMID: 29802206
Background: Atrial fibrillation (AF) is frequently associated with enhanced inflammatory response. The NLRP3 (NACHT, LRR, and PYD domain containing protein 3) inflammasome mediates caspase-1 activation and interleukin-1β release in immune...
13.
Rao L, Sha Y, Eissa N
Mol Cell Oncol
. 2017 Dec;
4(6):e1372867.
PMID: 29209655
TFEB is a master regulator for transcription of genes involved in autophagy, lysosome and mitochondrial biogenesis. Activity of TFEB is inhibited upon its phosphorylation. STUB1, a chaperone-dependent E3 ubiquitin ligase,...
14.
Khan A, Mann L, Papanna R, Lyu M, Singh C, Olson S, et al.
Sci Rep
. 2017 Nov;
7(1):15010.
PMID: 29118429
Human mesenchymal stem cells (MSCs) express scavenger receptors that internalize lipids, including oxidized low-density lipoprotein (oxLDL). We report that MSCs phagocytose Mycobacterium tuberculosis (Mtb) through two types of scavenger receptors...
15.
Sha Y, Rao L, Settembre C, Ballabio A, Eissa N
EMBO J
. 2017 Jul;
36(17):2544-2552.
PMID: 28754656
TFEB is a master regulator for transcription of genes involved in autophagy and lysosome biogenesis. Activity of TFEB is inhibited upon its serine phosphorylation by mTOR The overall mechanisms by...
16.
Lockyer P, Mao H, Fan Q, Li L, Yu-Lee L, Eissa N, et al.
Arterioscler Thromb Vasc Biol
. 2017 Jun;
37(8):1524-1535.
PMID: 28596374
Objective: Bacterial endotoxin (lipopolysaccharide)-mediated sepsis involves dysregulated systemic inflammation, which injures the lung and other organs, often fatally. Vascular endothelial cells act as both targets and mediators of lipopolysaccharide-induced inflammatory...
17.
Klionsky D, Abdelmohsen K, Abe A, Abedin M, Abeliovich H, Arozena A, et al.
Autophagy
. 2016 Jan;
12(1):1-222.
PMID: 26799652
No abstract available.
18.
Bhattacharya A, Wei Q, Shin J, Abdel Fattah E, Bonilla D, Xiang Q, et al.
Cell Rep
. 2015 Sep;
12(11):1731-9.
PMID: 26344765
Autophagy, an intracellular degradation and energy recycling mechanism, is emerging as an important regulator of immune responses. However, the role of autophagy in regulating neutrophil functions is not known. We...
19.
Watkin L, Jessen B, Wiszniewski W, Vece T, Jan M, Sha Y, et al.
Nat Genet
. 2015 Apr;
47(6):654-60.
PMID: 25894502
Unbiased genetic studies have uncovered surprising molecular mechanisms in human cellular immunity and autoimmunity. We performed whole-exome sequencing and targeted sequencing in five families with an apparent mendelian syndrome of...
20.
Abdel Fattah E, Bhattacharya A, Herron A, Safdar Z, Eissa N
J Immunol
. 2015 Apr;
194(11):5407-16.
PMID: 25888640
Autophagy is an important component of the immune response. However, the functions of autophagy in human diseases are much less understood. We studied biological consequences of autophagy deficiency in mice...