Abhisek Bhattacharya
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Explore the profile of Abhisek Bhattacharya including associated specialties, affiliations and a list of published articles.
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21
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569
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Recent Articles
1.
Zhang X, Bhattacharya A, Pu C, Dai Y, Liu J, Rao L, et al.
J Genet Genomics
. 2024 Jun;
51(12):1485-1493.
PMID: 38849111
Histone citrullination, an important post-translational modification mediated by peptidyl arginine deiminases, is essential for many physiological processes and epigenetic regulation. However, the causal relationship between histone citrullination and specific gene...
2.
Van Laethem F, Bhattacharya A, Craveiro M, Lu J, Sun P, Singer A
Front Immunol
. 2022 Aug;
13:953160.
PMID: 35911724
Understanding the generation of an MHC-restricted T cell repertoire is the cornerstone of modern T cell immunology. The unique ability of αβT cells to only recognize peptide antigens presented by...
3.
Shinzawa M, Moseman E, Gossa S, Mano Y, Bhattacharya A, Guinter T, et al.
Nat Immunol
. 2022 May;
23(5):731-742.
PMID: 35523960
T cell specificity and function are linked during development, as MHC-II-specific TCR signals generate CD4 helper T cells and MHC-I-specific TCR signals generate CD8 cytotoxic T cells, but the basis...
4.
Rao L, De La Rosa I, Xu Y, Sha Y, Bhattacharya A, Holtzman M, et al.
EMBO Rep
. 2020 Dec;
22(2):e50613.
PMID: 33345425
One major factor that contributes to the virulence of Pseudomonas aeruginosa is its ability to reside and replicate unchallenged inside airway epithelial cells. The mechanism by which P. aeruginosa escapes...
5.
Van Laethem F, Saba I, Lu J, Bhattacharya A, Tai X, Guinter T, et al.
Front Immunol
. 2020 Jul;
11:1216.
PMID: 32612609
MHC-independent αβTCRs (TCRs) recognize conformational epitopes on native self-proteins and arise in mice lacking both MHC and CD4/CD8 coreceptor proteins. Although naturally generated in the thymus, these TCRs resemble re-engineered...
6.
Rao L, Xu Y, Reineke L, Bhattacharya A, Tyryshkin A, Shin J, et al.
Int J Mol Sci
. 2020 Jun;
21(12).
PMID: 32560429
Alpha one antitrypsin (α1AT), a serine proteinase inhibitor primarily produced by the liver, protects pulmonary tissue from neutrophil elastase digestion. Mutations of the gene results in a misfolded α1AT protein...
7.
Lu J, Van Laethem F, Saba I, Chu J, Tikhonova A, Bhattacharya A, et al.
J Immunol
. 2020 Apr;
204(12):3351-3359.
PMID: 32321756
During normal T cell development in the thymus, αβ TCRs signal immature thymocytes to differentiate into mature T cells by binding to peptide-MHC ligands together with CD4/CD8 coreceptors. Conversely, in...
8.
Johnson J, Stoica L, Liu Y, Zhu P, Bhattacharya A, Buffington S, et al.
Neuron
. 2019 Oct;
104(4):665-679.e8.
PMID: 31585809
In humans, disruption of nonsense-mediated decay (NMD) has been associated with neurodevelopmental disorders (NDDs) such as autism spectrum disorder and intellectual disability. However, the mechanism by which deficient NMD leads...
9.
Lu J, Van Laethem F, Bhattacharya A, Craveiro M, Saba I, Chu J, et al.
Nat Commun
. 2019 Mar;
10(1):1019.
PMID: 30833553
The αβ T cell receptor (TCR) repertoire on mature T cells is selected in the thymus, but the basis for thymic selection of MHC-restricted TCRs from a randomly generated pre-selection...
10.
Bhattacharya A, Wei Q, Shin J, Abdel Fattah E, Bonilla D, Xiang Q, et al.
Cell Rep
. 2015 Sep;
12(11):1731-9.
PMID: 26344765
Autophagy, an intracellular degradation and energy recycling mechanism, is emerging as an important regulator of immune responses. However, the role of autophagy in regulating neutrophil functions is not known. We...