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N Tony Eissa

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Articles 59
Citations 9957
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Recent Articles
1.
Ebrahimpour A, Ahir M, Wang M, Jegga A, Bonnen M, Eissa N, et al.
Sci Rep . 2022 Nov; 12(1):20668. PMID: 36450789
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease of unknown etiology. Currently, pirfenidone and nintedanib are the only FDA-approved drugs for the treatment of IPF and are...
2.
Shin J, Rao L, Sha Y, Abdel Fattah E, Hyser J, Eissa N
J Immunol . 2021 Jul; 207(2):661-670. PMID: 34193605
Inflammation contributes to the pathogenesis and morbidity of wide spectrum of human diseases. The inflammatory response must be actively controlled to prevent bystander damage to tissues. Yet, the mechanisms controlling...
3.
Ebrahimpour A, Wang M, Li L, Jegga A, Bonnen M, Eissa N, et al.
J Inflamm (Lond) . 2021 May; 18(1):17. PMID: 34011367
Introduction: Idiopathic pulmonary fibrosis (IPF) is an orphan disease characterized by progressive loss of lung function resulting in shortness of breath and often death within 3-4 years of diagnosis. Repetitive...
4.
Klionsky D, Abdel-Aziz A, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, et al.
Autophagy . 2021 Feb; 17(1):1-382. PMID: 33634751
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our...
5.
Rao L, De La Rosa I, Xu Y, Sha Y, Bhattacharya A, Holtzman M, et al.
EMBO Rep . 2020 Dec; 22(2):e50613. PMID: 33345425
One major factor that contributes to the virulence of Pseudomonas aeruginosa is its ability to reside and replicate unchallenged inside airway epithelial cells. The mechanism by which P. aeruginosa escapes...
6.
Rao L, Xu Y, Reineke L, Bhattacharya A, Tyryshkin A, Shin J, et al.
Int J Mol Sci . 2020 Jun; 21(12). PMID: 32560429
Alpha one antitrypsin (α1AT), a serine proteinase inhibitor primarily produced by the liver, protects pulmonary tissue from neutrophil elastase digestion. Mutations of the gene results in a misfolded α1AT protein...
7.
Johnson J, Stoica L, Liu Y, Zhu P, Bhattacharya A, Buffington S, et al.
Neuron . 2019 Oct; 104(4):665-679.e8. PMID: 31585809
In humans, disruption of nonsense-mediated decay (NMD) has been associated with neurodevelopmental disorders (NDDs) such as autism spectrum disorder and intellectual disability. However, the mechanism by which deficient NMD leads...
8.
Khan A, Bakhru P, Saikolappan S, Das K, Soudani E, Singh C, et al.
NPJ Vaccines . 2019 Aug; 4:34. PMID: 31396406
BCG is widely used as a vaccine against tuberculosis due to (Mtb), which kills millions of people each year. BCG variably protects children, but not adults against tuberculosis. BCG evades...
9.
Rao L, Eissa N
J Innate Immun . 2019 Apr; 12(1):21-30. PMID: 31018206
Autophagy is a major intracellular digestion system that delivers cytoplasmic components for degradation and recycling. In this capacity, autophagy plays an important role in maintaining cellular homeostasis by mediating the...
10.
Ebrahimpour A, Shrestha S, Bonnen M, Eissa N, Raghu G, Ghebre Y
J Pharmacol Exp Ther . 2018 Nov; 368(2):169-178. PMID: 30446578
Idiopathic pulmonary fibrosis (IPF) is a fatal disease that destroys the structure and function of the lungs. Risk factors include advanced age and genetic predisposition. However, tobacco use is the...