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Lucas Massier

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Articles 29
Citations 525
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Recent Articles
1.
Zhong J, Zareifi D, Weinbrenner S, Hansen M, Klingelhuber F, Nono Nankam P, et al.
Cell Metab . 2025 Feb; 37(3):566-569. PMID: 39983713
We developed the Adipose Tissue Knowledge Portal by centralizing previously dispersed datasets, integrating clinical and experimental results with transcriptomic and proteomic data from >6,000 women and men. The platform includes...
2.
Patt M, Karkossa I, Krieg L, Massier L, Makki K, Tabei S, et al.
EBioMedicine . 2024 Nov; 110:105458. PMID: 39608059
Background: This research investigates the determinants of circulating FGF21 levels in a cohort reflecting metabolic disease progression, examining the associations of circulating FGF21 with morphology and function of adipose tissue...
3.
Hinte L, Castellano-Castillo D, Ghosh A, Melrose K, Gasser E, Noe F, et al.
Nature . 2024 Nov; 636(8042):457-465. PMID: 39558077
Reducing body weight to improve metabolic health and related comorbidities is a primary goal in treating obesity. However, maintaining weight loss is a considerable challenge, especially as the body seems...
4.
Savva C, Vlassakev I, Bunney B, Bunney W, Massier L, Seldin M, et al.
Biol Psychiatry Glob Open Sci . 2024 Oct; 4(6):100385. PMID: 39387094
Background: Chronic stress has a profound impact on circadian regulation of physiology. In turn, disruption of circadian rhythms increases the risk of developing both psychiatric and metabolic disorders. To explore...
5.
Lecoutre S, Maqdasy S, Rizo-Roca D, Renzi G, Vlassakev I, Alaeddine L, et al.
Nat Metab . 2024 Jul; 6(7):1329-1346. PMID: 39009762
Glutamine and glutamate are interconverted by several enzymes and alterations in this metabolic cycle are linked to cardiometabolic traits. Herein, we show that obesity-associated insulin resistance is characterized by decreased...
6.
Muller L, Hoffmann A, Bernhart S, Ghosh A, Zhong J, Hagemann T, et al.
EBioMedicine . 2024 Jul; 106:105242. PMID: 39002385
Background: Studies on DNA methylation following bariatric surgery have primarily focused on blood cells, while it is unclear to which extend it may reflect DNA methylation profiles in specific metabolically...
7.
Mashayekhi M, Sheng Q, Bailin S, Massier L, Zhong J, Shi M, et al.
Obesity (Silver Spring) . 2024 Jul; 32(8):1526-1540. PMID: 38967296
Objective: The objective of this study was to identify the transcriptional landscape of insulin resistance (IR) in subcutaneous adipose tissue (SAT) in humans across the spectrum of obesity. Methods: We...
8.
Massier L, Musat N, Stumvoll M, Tremaroli V, Chakaroun R, Kovacs P
Nat Metab . 2024 Jun; 6(7):1209-1224. PMID: 38898236
Although the impact of the gut microbiome on health and disease is well established, there is controversy regarding the presence of microorganisms such as bacteria and their products in organs...
9.
Klingelhuber F, Frendo-Cumbo S, Omar-Hmeadi M, Massier L, Kakimoto P, Taylor A, et al.
Nat Metab . 2024 Apr; 6(5):861-879. PMID: 38565923
White adipocytes function as major energy reservoirs in humans by storing substantial amounts of triglycerides, and their dysfunction is associated with metabolic disorders; however, the mechanisms underlying cellular specialization during...
10.
Arner P, Viguerie N, Massier L, Ryden M, Astrup A, Blaak E, et al.
Int J Obes (Lond) . 2024 Mar; 48(7):934-940. PMID: 38491191
Background/objective: Insulin resistance is more prominent in men than women. If this involves adipose tissue is unknown and was presently examined. Subjects/methods: AdipoIR (in vivo adipose insulin resistance index) was...