Motoki Takagi
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Explore the profile of Motoki Takagi including associated specialties, affiliations and a list of published articles.
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Articles
133
Citations
1274
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Recent Articles
11.
Ohsawa K, Yoshida M, Izumikawa M, Takagi M, Shin-Ya K, Goshima N, et al.
Bioorg Med Chem
. 2018 Nov;
26(23-24):6023-6034.
PMID: 30455074
The synthesis and biological evaluation of thielocin B1 analogues have been demonstrated. Fourteen analogues modified in the central core and terminal carboxylic acid moiety were concisely synthesized by simple esterification...
12.
Tamura H, Higa A, Hoshi H, Hiyama G, Takahashi N, Ryufuku M, et al.
Oncol Rep
. 2018 Jun;
40(2):635-646.
PMID: 29917168
Patient-derived tumor xenograft models represent a promising preclinical cancer model that better replicates disease, compared with traditional cell culture; however, their use is low-throughput and costly. To overcome this limitation,...
13.
Tsutsumi H, Katsuyama Y, Izumikawa M, Takagi M, Fujie M, Satoh N, et al.
J Am Chem Soc
. 2018 May;
140(21):6631-6639.
PMID: 29716187
Benzastatins have unique structures probably derived from geranylated p-aminobenzoic acids. The indoline and tetrahydroquinoline scaffolds are presumably formed by cyclization of the geranyl moiety, but the cyclization mechanism was unknown....
14.
Sato S, Takagi M, Miyoshi T
J Med Eng Technol
. 2018 Feb;
42(2):105-112.
PMID: 29448864
The purpose of this study was to develop a six-degree-of-freedom parallel mechanism moving platform to investigate the effects of multimodal sensory feedback information while standing upright. We constructed a custom-designed...
15.
Higa A, Hoshi H, Yanagisawa Y, Ito E, Morisawa G, Imai J, et al.
J Toxicol Sci
. 2017 Nov;
42(6):755-761.
PMID: 29142174
In recent years, human-induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs) have been widely used to develop evaluation systems for drug cardiotoxicity, including the arrhythmia caused by QT prolongation. To accurately assess...
16.
Ito S, Ogawa K, Takeuchi K, Takagi M, Yoshida M, Hirokawa T, et al.
J Biol Chem
. 2017 Oct;
292(49):20076-20085.
PMID: 29025875
Fibrosis can disrupt tissue structure and integrity and impair organ function. Fibrosis is characterized by abnormal collagen accumulation in the extracellular matrix. Pharmacological inhibition of collagen secretion therefore represents a...
17.
Hoshi H, Hiyama G, Ishikawa K, Inageda K, Fujimoto J, Wakamatsu A, et al.
Oncol Rep
. 2016 Nov;
37(1):66-76.
PMID: 27840973
Epidermal growth factor receptor (EGFR) overexpression and EGFR-mediated signaling pathway dysregulation have been observed in tumors from patients with various cancers, especially non-small cell lung cancer. Thus, several anti-EGFR drugs...
18.
Katsuyama Y, Sone K, Satou R, Izumikawa M, Takagi M, Fujie M, et al.
Chembiochem
. 2016 May;
17(11):1021-8.
PMID: 27158812
JBIR-76 and -77 are isofuranonaphthoquinones (IFNQs) isolated from Streptomyces sp. RI-77. Draft genome sequencing and gene disruption analysis of Streptomyces sp. RI-77 showed that a type II polyketide synthase (PKS)...
19.
Motohashi K, Izumikawa M, Kagaya N, Takagi M, Shin-Ya K
J Antibiot (Tokyo)
. 2016 Jan;
69(9):707-8.
PMID: 26732254
No abstract available.
20.
Ohno S, Katsuyama Y, Tajima Y, Izumikawa M, Takagi M, Fujie M, et al.
Chembiochem
. 2015 Sep;
16(16):2385-91.
PMID: 26403163
Streptazone derivatives isolated from Streptomyces species are piperidine alkaloids with a cyclopenta[b]pyridine scaffold. Previous studies indicated that these compounds are polyketides, but the biosynthetic enzymes responsible for their synthesis are...