Moritz Bunemann
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Explore the profile of Moritz Bunemann including associated specialties, affiliations and a list of published articles.
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74
Citations
2568
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Recent Articles
1.
Kirchhofer S, Kurz C, Geier L, Krett A, Krasel C, Bunemann M
Commun Biol
. 2025 Feb;
8(1):198.
PMID: 39920410
The opioid receptor family, particularly the µ opioid receptor, are the main drug targets in the management of severe pain. However, their pain-relieving effects are often accompanied by severe adverse...
2.
Kwon J, Kawase H, Mattonet K, Guenther S, Hahnefeld L, Shamsara J, et al.
Nat Commun
. 2025 Feb;
16(1):1448.
PMID: 39920161
Macrophages express numerous G protein-coupled receptors (GPCRs) that regulate adhesion, migration, and activation, but the function of orphan receptor GPRC5B in macrophages is unknown. Both resident peritoneal and bone marrow-derived...
3.
Rinne A, Bunemann M
Biomolecules
. 2025 Jan;
14(12.
PMID: 39766359
G protein-coupled receptors (GPCRs) regulate multiple cellular functions and represent important drug targets. More than 20 years ago, it was noted that GPCR activation (agonist binding) and signaling (G protein...
4.
Boutonnet M, Bunemann M, Perroy J
Pharmacol Ther
. 2024 Nov;
264:108741.
PMID: 39489434
In the landscape of proteins controlled by membrane voltage (V), like voltage-gated ionotropic channels, the emergence of the voltage sensitivity within the vast family of G-protein coupled receptors (GPCRs) marked...
5.
Drabek M, Emmerich R, Djulic N, Bunemann M, Schlitzer M, Kolb P
ChemMedChem
. 2024 Oct;
20(3):e202400633.
PMID: 39462201
We analyzed the precise ligand:receptor interactions required for activation of the muscarinic acetylcholine receptor M, a prototypical G protein-coupled receptor and potential diabetes target. Starting from literature-known compounds and docking...
6.
Kurz M, Ulrich M, Kirchhofer S, Bittner A, Daude M, Diederich W, et al.
Mol Pharmacol
. 2024 Sep;
106(5):216-224.
PMID: 39284672
Aberrant type 2 inflammatory responses are the underlying cause of the pathophysiology of allergic asthma, allergic rhinitis, and other atopic diseases, with an alarming prevalence in relevant parts of the...
7.
Krasel C, Bunemann M
Signal Transduct Target Ther
. 2024 Aug;
9(1):219.
PMID: 39209809
No abstract available.
8.
Wang T, Shao J, Kumar S, Alnouri M, Carvalho J, Gunther S, et al.
Circ Res
. 2024 Apr;
134(10):1259-1275.
PMID: 38597112
Background: GPCRs (G-protein-coupled receptors) play a central role in the regulation of smooth muscle cell (SMC) contractility, but the function of SMC-expressed orphan GPCR class C group 5 member C...
9.
Kurz M, Ulrich M, Bittner A, Bunemann M
Sci Rep
. 2024 Apr;
14(1):8178.
PMID: 38589416
The DP2 receptor is a G-protein coupled receptor involved in allergic inflammation and is the target of recently developed antagonists already being tested in clinics. To get insights into DP2...
10.
Kirchhofer S, Lim V, Ernst S, Karsai N, Ruland J, Canals M, et al.
Elife
. 2023 Nov;
12.
PMID: 37983079
The µ opioid receptor (MOR) is the key target for analgesia, but the application of opioids is accompanied by several issues. There is a wide range of opioid analgesics, differing...