Viacheslav O Nikolaev
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Explore the profile of Viacheslav O Nikolaev including associated specialties, affiliations and a list of published articles.
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173
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5967
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Recent Articles
1.
Kelly M, Nikolaev V, Gobejishvili L, Lugnier C, Hesslinger C, Nickolaus P, et al.
Pharmacol Rev
. 2025 Mar;
77(3):100042.
PMID: 40081105
Cyclic nucleotides are synthesized by adenylyl and/or guanylyl cyclase, and downstream of this synthesis, the cyclic nucleotide phosphodiesterase families (PDEs) specifically hydrolyze cyclic nucleotides. PDEs control cyclic adenosine-3',5'monophosphate (cAMP) and...
2.
Berisha F, Blankenberg S, Nikolaev V
Biomolecules
. 2024 Aug;
14(8).
PMID: 39199373
Sulfonylureas (SUs) are a class of antidiabetic drugs widely used in the management of diabetes mellitus type 2. They promote insulin secretion by inhibiting the ATP-sensitive potassium channel in pancreatic...
3.
Roslan A, Paulus K, Yang J, Matt L, Bischof H, Langst N, et al.
Cardiovasc Res
. 2024 Aug;
PMID: 39102831
Aims: Na+-activated Slack potassium (K+) channels are increasingly recognized as regulators of neuronal activity, yet little is known about their role in the cardiovascular system. Slack activity increases when intracellular...
4.
Pavlaki N, Froese A, Li W, De Jong K, Geertz B, Subramanian H, et al.
Cardiovasc Res
. 2024 May;
120(9):1011-1023.
PMID: 38776406
Aims: Gene therapy with cardiac phosphodiesterases (PDEs), such as phosphodiesterase 4B (PDE4B), has recently been described to effectively prevent heart failure (HF) in mice. However, exact molecular mechanisms of its...
5.
De Jong K, Siddig S, Pfeifer A, Nikolaev V
FEBS J
. 2024 May;
292(2):261-271.
PMID: 38747241
White and brown adipocytes are central mediators of lipid metabolism and thermogenesis, respectively. Their function is tightly regulated by all three β-adrenergic receptor (β-AR) subtypes which are coupled to the...
6.
Balykina A, Naida L, Kirkgoz K, Nikolaev V, Fock E, Belyakov M, et al.
Int J Mol Sci
. 2024 May;
25(9).
PMID: 38732081
Flavonoid aglycones are secondary plant metabolites that exhibit a broad spectrum of pharmacological activities, including anti-inflammatory, antioxidant, anticancer, and antiplatelet effects. However, the precise molecular mechanisms underlying their inhibitory effect...
7.
Subramanian H, Nikolaev V
Circ Res
. 2024 Apr;
134(8):1023-1025.
PMID: 38603476
No abstract available.
8.
Kraft A, Bork N, Subramanian H, Pavlaki N, Failla A, Zobiak B, et al.
Cells
. 2024 Mar;
13(6.
PMID: 38534320
The ubiquitous second messenger 3',5'-cyclic adenosine monophosphate (cAMP) regulates cardiac excitation-contraction coupling (ECC) by signaling in discrete subcellular microdomains. Phosphodiesterase subfamilies 4B and 4D are critically involved in the regulation...
9.
Bielenberg M, Kurelic R, Frantz S, Nikolaev V
Front Immunol
. 2024 Mar;
15:1365484.
PMID: 38524120
T-cell activation is a pivotal process of the adaptive immune response with 3',5'-cyclic adenosine monophosphate (cAMP) as a key regulator of T-cell activation and function. It governs crucial control over...
10.
The phosphodiesterase 2A controls lymphatic junctional maturation via cGMP-dependent notch signaling
Carlantoni C, Liekfeld L, Hemkemeyer S, Schreier D, Saygi C, Kurelic R, et al.
Dev Cell
. 2023 Dec;
59(3):308-325.e11.
PMID: 38159569
The molecular mechanisms by which lymphatic vessels induce cell contact inhibition are not understood. Here, we identify the cGMP-dependent phosphodiesterase 2A (PDE2A) as a selective regulator of lymphatic but not...