Mohammed El-Mezgueldi
Overview
Explore the profile of Mohammed El-Mezgueldi including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
292
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0
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Recent Articles
1.
Parijat P, Ponnam S, Attili S, Campbell K, El-Mezgueldi M, Pfuhl M, et al.
Sci Rep
. 2023 Mar;
13(1):5216.
PMID: 36997544
The large unmet demand for new heart failure therapeutics is widely acknowledged. Over the last decades the contractile myofilaments themselves have emerged as an attractive target for the development of...
2.
Messer A, Bayliss C, El-Mezgueldi M, Redwood C, Ward D, Leung M, et al.
Arch Biochem Biophys
. 2016 Apr;
601:113-20.
PMID: 27036851
We investigated the effect of 7 Hypertrophic Cardiomyopathy (HCM)-causing mutations in troponin T (TnT) on troponin function in thin filaments reconstituted with actin and human cardiac tropomyosin. We used the...
3.
Marshall J, Faraj B, Gingras A, Lonnen R, Sheikh M, El-Mezgueldi M, et al.
Sci Rep
. 2015 Sep;
5:13293.
PMID: 26333773
Pneumolysin is a cholesterol-dependent cytolysin (CDC) and virulence factor of Streptococcus pneumoniae. It kills cells by forming pores assembled from oligomeric rings in cholesterol-containing membranes. Cryo-EM has revealed the structures...
4.
Venkatraman Girija U, Furze C, Gingras A, Yoshizaki T, Ohtani K, Marshall J, et al.
BMC Biol
. 2015 Apr;
13:27.
PMID: 25912189
Background: Collectin-K1 (CL-K1, or CL-11) is a multifunctional Ca(2+)-dependent lectin with roles in innate immunity, apoptosis and embryogenesis. It binds to carbohydrates on pathogens to activate the lectin pathway of...
5.
Itoh T, Fairall L, Muskett F, Milano C, Watson P, Arnaudo N, et al.
Nucleic Acids Res
. 2015 Feb;
43(4):2033-44.
PMID: 25653165
Recent proteomic studies have identified a novel histone deacetylase complex that is upregulated during mitosis and is associated with cyclin A. This complex is conserved from nematodes to man and...
6.
El-Mezgueldi M
J Muscle Res Cell Motil
. 2014 Feb;
35(3-4):203-10.
PMID: 24510226
Tropomyosin is a two chained α-helical coiled coil protein that binds actin filaments and interacts with various actin binding proteins. Tropomyosin function depends on its ability to move to distinct...
7.
Marston S, Memo M, Messer A, Papadaki M, Nowak K, McNamara E, et al.
Hum Mol Genet
. 2013 Jul;
22(24):4978-87.
PMID: 23886664
The congenital myopathies include a wide spectrum of clinically, histologically and genetically variable neuromuscular disorders many of which are caused by mutations in genes for sarcomeric proteins. Some congenital myopathy...
8.
Jensen M, Watt J, Hodgkinson J, Gallant C, Appel S, El-Mezgueldi M, et al.
Cytoskeleton (Hoboken)
. 2011 Dec;
69(1):49-58.
PMID: 22135101
The cellular actin cytoskeleton plays a central role in the ability of cells to properly sense, propagate, and respond to external stresses and other mechanical stimuli. Calponin, an actin-binding protein...
9.
Fogl C, Puckey L, Hinssen U, Zaleska M, El-Mezgueldi M, Croasdale R, et al.
Proteins
. 2011 Nov;
80(2):398-409.
PMID: 22081479
MS1 is a protein predominantly expressed in cardiac and skeletal muscle that is upregulated in response to stress and contributes to development of hypertrophy. In the aortic banding model of...
10.
Pfuhl M, Al-Sarayreh S, El-Mezgueldi M
Biophys J
. 2011 Apr;
100(7):1718-28.
PMID: 21463585
Calponin is an actin- and calmodulin-binding protein believed to regulate the function of actin. Low-resolution studies based on proteolysis established that the recombinant calponin fragment 131-228 contained actin and calmodulin...