Mohammed El-Mezgueldi
Overview
Explore the profile of Mohammed El-Mezgueldi including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
292
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0
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Recent Articles
11.
Ansari S, Alahyan M, Marston S, El-Mezgueldi M
J Biol Chem
. 2007 Oct;
283(1):47-56.
PMID: 17933868
Smooth muscle thin filaments are made up of actin, tropomyosin, caldesmon, and a Ca(2+)-binding protein and their interaction with myosin is Ca(2+)-regulated. We suggested that Ca(2+) regulation by caldesmon and...
12.
Mirza M, Robinson P, Kremneva E, Copeland O, Nikolaeva O, Watkins H, et al.
J Biol Chem
. 2007 Mar;
282(18):13487-97.
PMID: 17360712
E40K and E54K mutations in alpha-tropomyosin cause inherited dilated cardiomyopathy. Previously we showed, using Ala-Ser alpha-tropomyosin (AS-alpha-Tm) expressed in Escherichia coli, that both mutations decrease Ca(2+) sensitivity. E40K also reduces...
13.
Alahyan M, Webb M, Marston S, El-Mezgueldi M
J Biol Chem
. 2006 Mar;
281(28):19433-48.
PMID: 16540476
Caldesmon is a component of smooth muscle thin filaments that inhibits the actomyosin ATPase via its interaction with actin-tropomyosin. We have performed a comprehensive transient kinetic characterization of the actomyosin...
14.
Ansari S, El-Mezgueldi M, Marston S
J Muscle Res Cell Motil
. 2004 Feb;
24(8):513-20.
PMID: 14870966
We measured the inhibition of actin activated myosin subfragment-1 MgATPase activity in a solution containing no added KCl (5 mM PIPES.K2 (pH 7.1), 2.5 mM MgCl2, 1 mM DTT, 1...
15.
Patchell V, Vorotnikov A, Gao Y, Low D, Evans J, Fattoum A, et al.
Biochim Biophys Acta
. 2002 May;
1596(1):121-30.
PMID: 11983427
Caldesmon is an inhibitory protein believed to be involved in the regulation of thin filament activity in smooth muscles and is a major cytoplasmic substrate for MAP kinase. NMR spectroscopy...