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» Authors » Mohamed M Mohyeldin

Mohamed M Mohyeldin

Explore the profile of Mohamed M Mohyeldin including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 24
Citations 367
Followers 0
Related Specialties
Pharmacology
Chemistry
Biochemistry
Top 10 Co-Authors
Khalid A El Sayed
Hassan Y Ebrahim
Mohamed R Akl
Abu Bakar Siddique
Nehad M Ayoub
Heba E Elsayed
James A Cardelli
Amira A Goda
Eman Shawky
Ahmed I Foudah
Published In
Bioorg Med Chem
Phytother Res
Oncotarget
Fitoterapia
PLoS One
Affiliations
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Recent Articles
11.
Acylated Iridoids and Rhamnopyranoses from Premna odorata (Lamiaceae) as Novel Mesenchymal-Epithelial Transition Factor Receptor Inhibitors for the Control of Breast Cancer
Elmaidomy A, Mohyeldin M, Ibrahim M, Hassan H, Amin E, Rateb M, et al.
Phytother Res . 2017 Aug; 31(10):1546-1556. PMID: 28809058
Phytochemical investigation of Premna odorata Blanco, Lamiaceae, leaves afforded three new acylated iridoid glycosides 1-3 and two new acylated rhamnopyranoses 9 and 10, in addition to ten known compounds. The...
12.
The olive oil phenolic (-)-oleocanthal modulates estrogen receptor expression in luminal breast cancer in vitro and in vivo and synergizes with tamoxifen treatment
Ayoub N, Siddique A, Ebrahim H, Mohyeldin M, El Sayed K
Eur J Pharmacol . 2017 Jun; 810:100-111. PMID: 28625568
Luminal breast cancer represents a therapeutic challenge in terms of aggressive disease and emerging resistance to targeted therapy. (-)-Oleocanthal has demonstrated anticancer activity in multiple human cancers. The goal of...
13.
The tobacco cembranoid (1S,2E,4S,7E,11E)-2,7,11-cembratriene-4,6-diol as a novel angiogenesis inhibitory lead for the control of breast malignancies
Hailat M, Ebrahim H, Mohyeldin M, Goda A, Siddique A, El Sayed K
Bioorg Med Chem . 2017 Jun; 25(15):3911-3921. PMID: 28583806
(1S,2E,4S,6R,7E,11E)-2,7,11-cembratriene-4,6-diol (1) and its 4-epi-analog (2) are diterpene precursors of the key flavor components in most Nicotiana (tobacco) species that purposely degraded during commercial tobacco fermentation. Angiogenesis, recruitment of new...
14.
The marine-derived pachycladin diterpenoids as novel inhibitors of wild-type and mutant EGFR
Mohyeldin M, Akl M, Siddique A, Hassan H, El Sayed K
Biochem Pharmacol . 2016 Dec; 126:51-68. PMID: 27940262
Epidermal growth factor receptor (EGFR) is a key player in proliferation and metastasis of various cancers. Discovery of novel EGFR inhibitors is still an urgent clinical oncology unmet need. Pachycladins...
15.
(1S,2E,4S,7E,11E)-2,7,11-Cembratriene-4,6-diol semisynthetic analogs as novel c-Met inhibitors for the control of c-Met-dependent breast malignancies
Ebrahim H, Mohyeldin M, Hailat M, El Sayed K
Bioorg Med Chem . 2016 Sep; 24(22):5748-5761. PMID: 27681240
(1S,2E,4S,6R,7E,11E)-2,7,11-Cembratriene-4,6-diol (1) and its 4-epi-analog (2) are the cembranoid precursors to several key flavor ingredients in most Nicotiana (tobacco) species. Nearly 40-60% of 1 and 2 are purposely degraded during...
16.
Novel c-Met inhibitory olive secoiridoid semisynthetic analogs for the control of invasive breast cancer
Mohyeldin M, Busnena B, Akl M, Dragoi A, Cardelli J, El Sayed K
Eur J Med Chem . 2016 Jun; 118:299-315. PMID: 27258622
Dysregulated receptor tyrosine kinase c-Met and its ligand HGF is valid and attractive molecular target for therapeutic blockade in cancer. Inspired by the chemical structure of the naturally occurring olive...
17.
The oleocanthal-based homovanillyl sinapate as a novel c-Met inhibitor
Mohyeldin M, Akl M, Ebrahim H, Dragoi A, Dykes S, Cardelli J, et al.
Oncotarget . 2016 Apr; 7(22):32247-73. PMID: 27086914
The hepatocyte growth factor (HGF)/mesenchymal-epithelial transition factor (c-Met) signaling axis has gained considerable attention as an attractive molecular target for therapeutic blockade of cancer. Inspired by the chemical structure of...
18.
Norstictic Acid Inhibits Breast Cancer Cell Proliferation, Migration, Invasion, and In Vivo Invasive Growth Through Targeting C-Met
Ebrahim H, Elsayed H, Mohyeldin M, Akl M, Bhattacharjee J, Egbert S, et al.
Phytother Res . 2016 Jan; 30(4):557-66. PMID: 26744260
Breast cancer is a major health problem affecting the female population worldwide. The triple-negative breast cancers (TNBCs) are characterized by malignant phenotypes, worse patient outcomes, poorest prognosis, and highest mortality...
19.
The indole alkaloid meleagrin, from the olive tree endophytic fungus Penicillium chrysogenum, as a novel lead for the control of c-Met-dependent breast cancer proliferation, migration and invasion
Mady M, Mohyeldin M, Ebrahim H, Elsayed H, Houssen W, Haggag E, et al.
Bioorg Med Chem . 2015 Dec; 24(2):113-22. PMID: 26692349
Fungi of the genus Penicillium produce unique and chemically diverse biologically active secondary metabolites, including indole alkaloids. The role of dysregulated hepatocyte growth factor (HGF) and its receptor, c-Met, in...
20.
Isothiocyanatostilbenes as novel c-Met inhibitors
Gray A, Coleman D, Castore R, Mohyeldin M, El Sayed K, Cardelli J
Oncotarget . 2015 Nov; 6(38):41180-93. PMID: 26543230
The hepatocyte growth factor receptor (HGFR or c-Met) is a driver of multiple cancer subtypes. While there are several c-Met inhibitors in development, few have been approved for clinical use,...