Mohamed R Akl
Overview
Explore the profile of Mohamed R Akl including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
25
Citations
447
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Siddique A, Ebrahim H, Akl M, Ayoub N, Goda A, Mohyeldin M, et al.
Nutrients
. 2019 Feb;
11(2).
PMID: 30781364
Dysregulation of epidermal growth factor receptor (EGFR)/human epidermal growth factor-2 (HER2) family is a hallmark of aggressive breast cancer. Small-molecule tyrosine kinase inhibitors are among the most effective cancer targeted...
2.
Ebrahim H, Akl M, Elsayed H, Hill R, El Sayed K
J Nat Prod
. 2017 Mar;
80(4):932-952.
PMID: 28245124
(+)-Usnic acid (1) is a common bioactive lichen-derived secondary metabolite with a characteristic dibenzofuran scaffold. It displayed low micromolar antiproliferative activity levels and, notably, induced autophagy in a panel of...
3.
Mohyeldin M, Akl M, Siddique A, Hassan H, El Sayed K
Biochem Pharmacol
. 2016 Dec;
126:51-68.
PMID: 27940262
Epidermal growth factor receptor (EGFR) is a key player in proliferation and metastasis of various cancers. Discovery of novel EGFR inhibitors is still an urgent clinical oncology unmet need. Pachycladins...
4.
Nagpal P, Akl M, Ayoub N, Tomiyama T, Cousins T, Tai B, et al.
Oncotarget
. 2016 Aug;
7(41):67551-67573.
PMID: 27563824
Hodgkin lymphoma (HL) is a lymphoid malignancy that is typically derived from germinal-center B cells. EBV infection, mutations in NF-κB pathway genes, and genetic susceptibility are known risk factors for...
5.
Mohyeldin M, Busnena B, Akl M, Dragoi A, Cardelli J, El Sayed K
Eur J Med Chem
. 2016 Jun;
118:299-315.
PMID: 27258622
Dysregulated receptor tyrosine kinase c-Met and its ligand HGF is valid and attractive molecular target for therapeutic blockade in cancer. Inspired by the chemical structure of the naturally occurring olive...
6.
Mohyeldin M, Akl M, Ebrahim H, Dragoi A, Dykes S, Cardelli J, et al.
Oncotarget
. 2016 Apr;
7(22):32247-73.
PMID: 27086914
The hepatocyte growth factor (HGF)/mesenchymal-epithelial transition factor (c-Met) signaling axis has gained considerable attention as an attractive molecular target for therapeutic blockade of cancer. Inspired by the chemical structure of...
7.
Akl M, Nagpal P, Ayoub N, Tai B, Prabhu S, Capac C, et al.
Oncotarget
. 2016 Mar;
7(28):44735-44762.
PMID: 27007053
Fibroblast growth factor (FGF) signaling is essential for normal and cancer biology. Mammalian FGF family members participate in multiple signaling pathways by binding to heparan sulfate and FGF receptors (FGFR)...
8.
Ebrahim H, Elsayed H, Mohyeldin M, Akl M, Bhattacharjee J, Egbert S, et al.
Phytother Res
. 2016 Jan;
30(4):557-66.
PMID: 26744260
Breast cancer is a major health problem affecting the female population worldwide. The triple-negative breast cancers (TNBCs) are characterized by malignant phenotypes, worse patient outcomes, poorest prognosis, and highest mortality...
9.
Akl M, Nagpal P, Ayoub N, Prabhu S, Gliksman M, Tai B, et al.
Oncotarget
. 2015 Aug;
6(30):28693-715.
PMID: 26293675
Syndecan-1 (SDC1, CD138) is a key cell surface adhesion molecule essential for maintaining cell morphology and interaction with the surrounding microenvironment. Deregulation of SDC1 contributes to cancer progression by promoting...
10.
Khanfar M, Bardaweel S, Akl M, El Sayed K
Phytother Res
. 2015 Aug;
29(11):1776-82.
PMID: 26248874
The established anticancer and neuroprotective properties of oleocanthal combined with the reported role of mammalian target of rapamycin (mTOR) in cancer and Alzheimer's disease development encouraged us to examine the...