Mitchell D Shub
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Explore the profile of Mitchell D Shub including associated specialties, affiliations and a list of published articles.
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14
Citations
258
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Recent Articles
1.
Dooley S, Kolobova E, Burman A, Kaji I, Digrazia J, Stubler R, et al.
Gastroenterology
. 2024 Sep;
168(1):84-98.e9.
PMID: 39299401
Background & Aims: The xenobiotic efflux pump P-glycoprotein is highly expressed on the apical membrane of the gastrointestinal tract, where it regulates the levels of intracellular substrates. P-glycoprotein is altered...
2.
Kalashyan M, Raghunathan K, Oller H, Bayer M, Jimenez L, Roland J, et al.
J Clin Invest
. 2023 Aug;
133(20).
PMID: 37643022
Microvillus inclusion disease (MVID), caused by loss-of-function mutations in the motor protein myosin Vb (MYO5B), is a severe infantile disease characterized by diarrhea, malabsorption, and acid/base instability, requiring intensive parenteral...
3.
Kalashyan M, Raghunathan K, Oller H, Theres M, Jimenez L, Roland J, et al.
bioRxiv
. 2023 Feb;
PMID: 36747680
Conflict-of-interest Statement: The authors have declared that no conflict of interest exists.
4.
Engevik A, Coutts A, Kaji I, Rodriguez P, Ongaratto F, Saqui-Salces M, et al.
Gastroenterology
. 2020 Mar;
158(8):2236-2249.e9.
PMID: 32112796
Background & Aims: Microvillus inclusion disease (MVID) is caused by inactivating mutations in the myosin VB gene (MYO5B). MVID is a complex disorder characterized by chronic, watery, life-threatening diarrhea that...
5.
Engevik A, Kaji I, Engevik M, Meyer A, Weis V, Goldstein A, et al.
Gastroenterology
. 2018 Aug;
155(6):1883-1897.e10.
PMID: 30144427
Background & Aims: Inactivating mutations in MYO5B cause microvillus inclusion disease (MVID), but the physiological cause of the diarrhea associated with this disease is unclear. We investigated whether loss of...
6.
Schlegel C, Weis V, Knowles B, Lapierre L, Martin M, Dickman P, et al.
Dig Dis Sci
. 2017 Dec;
63(2):356-365.
PMID: 29218485
Objectives: Microvillus inclusion disease (MVID) is a severe form of neonatal diarrhea, caused mainly by mutations in MYO5B. Inactivating mutations in MYO5B causes depolarization of enterocytes in the small intestine,...
7.
Thakkar K, Holub J, Gilger M, Shub M, McOmber M, Tsou M, et al.
Gastrointest Endosc
. 2015 Aug;
83(3):533-41.
PMID: 26253014
Background And Aims: Currently, there are no quality measures specific to children undergoing GI endoscopy. We aimed to determine the baseline quality of pediatric colonoscopy by using the Pediatric Endoscopy...
8.
Shub M
Curr Opin Pediatr
. 2015 Jul;
27(5):609-13.
PMID: 26196260
Purpose Of Review: This review will focus on therapeutic considerations and recent advances in treatment of caustic ingestion injuries. Recent Findings: A retrospective study suggests that it may be safe...
9.
Knowles B, Weis V, Yu S, Roland J, Williams J, Alvarado G, et al.
J Cell Sci
. 2015 Feb;
128(8):1617-26.
PMID: 25673875
Rab11a is a key component of the apical recycling endosome that aids in the trafficking of proteins to the luminal surface in polarized epithelial cells. Utilizing conditional Rab11a-knockout specific to...
10.
Knowles B, Roland J, Krishnan M, Tyska M, Lapierre L, Dickman P, et al.
J Clin Invest
. 2014 Jun;
124(7):2947-62.
PMID: 24892806
Microvillus inclusion disease (MVID) is a severe form of congenital diarrhea that arises from inactivating mutations in the gene encoding myosin Vb (MYO5B). We have examined the association of mutations...