James R Goldenring
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Explore the profile of James R Goldenring including associated specialties, affiliations and a list of published articles.
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239
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7527
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Recent Articles
1.
Bowman D, Meenderink L, Thomas K, Manning E, Tyska M, Goldenring J
J Biol Chem
. 2025 Feb;
:108328.
PMID: 39978676
Microvillus Inclusion Disease (MVID) is a rare congenital diarrheal disorder typically caused by loss of function mutations in the unconventional myosin, Myosin 5b (MYO5B), which leads to the mis-trafficking of...
2.
Pariani A, Huhn V, Maknis T, Alonso V, Almada E, Vena R, et al.
bioRxiv
. 2025 Feb;
PMID: 39896676
Summary Sentence: The Golgi apparatus (GA) functions as a microtubule-organizing center (MTOC) in NK cells. During the recognition of tumoral cells by NK cells, CLASP1/2-mediated stabilization of GA-derived microtubules (GDMTs)...
3.
Javerfelt S, Hellsen G, Kaji I, Goldenring J, Pelaseyed T
Biochem J
. 2024 Dec;
482(1):1-23.
PMID: 39661054
A dense glycocalyx, composed of the megaDalton-sized membrane mucin MUC17, coats the microvilli in the apical brush border of transporting intestinal epithelial cells, called enterocytes. The formation of the MUC17-based...
4.
Momoh M, Rathan-Kumar S, Burman A, Brown M, Adeniran F, Ramos C, et al.
Am J Physiol Gastrointest Liver Physiol
. 2024 Oct;
327(6):G877-G899.
PMID: 39404772
Functional loss of the motor protein myosin Vb (MYO5B) induces various defects in intestinal epithelial function and causes a congenital diarrheal disorder, namely, microvillus inclusion disease (MVID). Utilizing the MVID...
5.
Dooley S, Kolobova E, Burman A, Kaji I, Digrazia J, Stubler R, et al.
Gastroenterology
. 2024 Sep;
168(1):84-98.e9.
PMID: 39299401
Background & Aims: The xenobiotic efflux pump P-glycoprotein is highly expressed on the apical membrane of the gastrointestinal tract, where it regulates the levels of intracellular substrates. P-glycoprotein is altered...
6.
Momoh M, Rathan-Kumar S, Burman A, Brown M, Adeniran F, Ramos C, et al.
bioRxiv
. 2024 Sep;
PMID: 39282272
New & Notewothy: This study demonstrates the importance of MYO5B for cellular lipid metabolism and mitochondria in intestinal epithelial cells, a previously unexplored function of MYO5B. Alterations in cellular metabolism...
7.
Rhodes J, Goldenring J, Lee S
Exp Mol Med
. 2024 Jun;
56(6):1322-1330.
PMID: 38825636
Research on the microenvironment associated with gastric carcinogenesis has focused on cancers of the stomach and often underestimates premalignant stages such as metaplasia and dysplasia. Since epithelial interactions with T...
8.
Contreras-Panta E, Lee S, Won Y, Norlander A, Simmons A, Peebles Jr R, et al.
Cell Mol Gastroenterol Hepatol
. 2024 May;
18(3):101366.
PMID: 38815928
Background & Aims: Type 2 innate lymphoid cells (ILC2s) and interleukin-13 (IL-13) promote the onset of spasmolytic polypeptide-expressing metaplasia (SPEM) cells. However, little is known about molecular effects of IL-13...
9.
Kaji I, Thiagarajah J, Goldenring J
J Cell Biol
. 2024 Apr;
223(7).
PMID: 38683247
Monogenetic variants are responsible for a range of congenital human diseases. Variants in genes that are important for intestinal epithelial function cause a group of disorders characterized by severe diarrhea...
10.
Sohn Y, Flores Semyonov B, El-Mekkoussi H, Wright C, Kaestner K, Choi E, et al.
Cell Mol Gastroenterol Hepatol
. 2024 Apr;
18(2):101347.
PMID: 38670488
Background & Aim: Telocytes, a recently identified type of subepithelial interstitial cell, have garnered attention for their potential roles in tissue homeostasis and repair. However, their contribution to gastric metaplasia...