Milton To
Overview
Explore the profile of Milton To including associated specialties, affiliations and a list of published articles.
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11
Citations
884
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Recent Articles
1.
Cattaruzza F, Nazeer A, To M, Hammond M, Koski C, Liu L, et al.
Nat Cancer
. 2023 Mar;
4(4):485-501.
PMID: 36997747
To enhance the therapeutic index of T-cell engagers (TCEs), we engineered masked, precision-activated TCEs (XPAT proteins), targeting a tumor antigen (human epidermal growth factor receptor 2 (HER2) or epidermal growth...
2.
Peterson C, Deol K, To M, Olzmann J
STAR Protoc
. 2021 Jun;
2(2):100579.
PMID: 34151299
Lipid droplets are endoplasmic reticulum-derived neutral lipid storage organelles that play critical roles in cellular lipid and energy homeostasis. Here, we present a protocol for the identification of high-confidence lipid...
3.
Barajas J, Wehrs M, To M, Cruickshanks L, Urban R, McKee A, et al.
J Microbiol Biol Educ
. 2019 Aug;
20(2).
PMID: 31388393
The conversion of biomass to biofuels presents a solution to one of the largest global challenges of our era, climate change. A critical part of this pipeline is the process...
4.
Spradlin J, Hu X, Ward C, Brittain S, Jones M, Ou L, et al.
Nat Chem Biol
. 2019 Jun;
15(7):747-755.
PMID: 31209351
Nimbolide, a terpenoid natural product derived from the Neem tree, impairs cancer pathogenicity; however, the direct targets and mechanisms by which nimbolide exerts its effects are poorly understood. Here, we...
5.
Berdan C, Ho R, Lehtola H, To M, Hu X, Huffman T, et al.
Cell Chem Biol
. 2019 May;
26(7):1027-1035.e22.
PMID: 31080076
Parthenolide, a natural product from the feverfew plant and member of the large family of sesquiterpene lactones, exerts multiple biological and therapeutic activities including anti-inflammatory and anti-cancer effects. Here, we...
6.
Magtanong L, Ko P, To M, Cao J, Forcina G, Tarangelo A, et al.
Cell Chem Biol
. 2019 Jan;
26(3):420-432.e9.
PMID: 30686757
The initiation and execution of cell death can be regulated by various lipids. How the levels of environmental (exogenous) lipids impact cell death sensitivity is not well understood. We find...
7.
Huang E, To M, Tran E, Dionisio L, Cho H, Baney K, et al.
Mol Biol Cell
. 2018 Mar;
29(9):1021-1030.
PMID: 29514927
Endoplasmic reticulum (ER)-associated degradation (ERAD) mediates the proteasomal clearance of proteins from the early secretory pathway. In this process, ubiquitinated substrates are extracted from membrane-embedded dislocation complexes by the AAA...
8.
Bersuker K, Peterson C, To M, Sahl S, Savikhin V, Grossman E, et al.
Dev Cell
. 2017 Dec;
44(1):97-112.e7.
PMID: 29275994
Lipid droplet (LD) functions are regulated by a complement of integral and peripheral proteins that associate with the bounding LD phospholipid monolayer. Defining the composition of the LD proteome has...
9.
Anderson K, To M, Olzmann J, Nomura D
ACS Chem Biol
. 2017 Sep;
12(10):2522-2528.
PMID: 28892616
Covalent ligand discovery is a promising strategy to develop small-molecule effectors against therapeutic targets. Recent studies have shown that dichlorotriazines are promising reactive scaffolds that preferentially react with lysines. Here,...
10.
To M, Peterson C, Roberts M, Counihan J, Wu T, Forster M, et al.
Mol Biol Cell
. 2016 Nov;
28(2):270-284.
PMID: 27881664
The endoplasmic reticulum (ER) mediates the folding, maturation, and deployment of the secretory proteome. Proteins that fail to achieve their native conformation are retained in the ER and targeted for...