Thomas J Maimone
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Explore the profile of Thomas J Maimone including associated specialties, affiliations and a list of published articles.
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62
Citations
2560
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Recent Articles
1.
Rosen H, Li K, Li E, Currier B, Brittain S, Garcia F, et al.
bioRxiv
. 2025 Mar;
PMID: 40060528
While MYC is a significant oncogenic transcription factor driver of cancer, directly targeting MYC has remained challenging due to its intrinsic disorder and poorly defined structure, deeming it "undruggable." Whether...
2.
Sanchez A, Gonzalez V, Sakamoto J, Gurajapu A, Maimone T
J Am Chem Soc
. 2024 Jun;
146(26):17573-17579.
PMID: 38901002
Dynamic, shapeshifting hydrocarbons have emerged as enabling frameworks across drug discovery, materials science, and catalysis. Their employment, however, is often hampered by a lack of efficient synthetic methods for their...
3.
Gowans F, Thach D, Zhu Z, Wang Y, Altamirano Poblano B, Dovala D, et al.
ACS Chem Biol
. 2024 May;
19(6):1260-1270.
PMID: 38739449
Ophiobolin A (OPA) is a sesterterpenoid fungal natural product with broad anticancer activity. While OPA possesses multiple electrophilic moieties that can covalently react with nucleophilic amino acids on proteins, the...
4.
Harmange Magnani C, Hernandez-Melendez J, Tantillo D, Maimone T
JACS Au
. 2023 Oct;
3(10):2883-2893.
PMID: 37885570
Monoterpene alkaloids encompass distinct chemical diversity and wide-ranging bioactivity. Their compact complexity has made them popular as synthetic targets and has inspired many distinct strategies and tactics in the field...
5.
Zhu Z, Maimone T
J Am Chem Soc
. 2023 Jun;
145(26):14215-14220.
PMID: 37343162
Marine bryozoans continue to provide architecturally fascinating halogenated alkaloids that pose unique challenges for chemical synthesis. The antimalarial alkaloids caulamidines A and B, recently isolated from , contain an intricate...
6.
Sanchez A, Gurajapu A, Guo W, Kong W, Laconsay C, Settineri N, et al.
J Am Chem Soc
. 2023 Jun;
145(24):13452-13461.
PMID: 37279177
Polycyclic ring systems are ubiquitous three-dimensional (3D) structural motifs central to the function of many biologically active small molecules and organic materials. Indeed, subtle changes to the overall molecular shape...
7.
Belcher B, Machicao P, Tong B, Ho E, Friedli J, So B, et al.
Chembiochem
. 2023 Mar;
24(14):e202300111.
PMID: 36964942
Chlorinated gymnastatin and dankastatin alkaloids derived from the fungal strain Gymnascella dankaliensis have been reported to possess significant anticancer activity but their mode of action is unknown. These members possess...
8.
Gowans F, Thach D, Wang Y, Altamirano Poblano B, Dovala D, Tallarico J, et al.
bioRxiv
. 2023 Mar;
PMID: 36945520
Ophiobolin A (OPA) is a sesterterpenoid fungal natural product with broad anti-cancer activity. While OPA possesses multiple electrophilic moieties that can covalently react with nucleophilic amino acids on proteins, the...
9.
Belcher B, Machicao P, Tong B, Ho E, Friedli J, So B, et al.
bioRxiv
. 2023 Feb;
PMID: 36798342
Chlorinated gymnastatin and dankastatin alkaloids derived from the fungal strain have been reported to possess significant anti-cancer activity but their mode of action is unknown. These members possess electrophilic functional...
10.
Vasilev V, Spessert L, Yu K, Maimone T
J Am Chem Soc
. 2022 Aug;
144(36):16332-16337.
PMID: 36043948
From both structural and functional perspectives, the large family of daphnane diterpene orthoesters (DDOs) represent a truly remarkable class of natural products. As potent lead compounds for the treatment of...