Alpha 2.0
Login Register
» Authors » Mikhail M Raihstat

Mikhail M Raihstat

Explore the profile of Mikhail M Raihstat including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 8
Citations 53
Followers 0
Related Specialties
Chemistry
Biochemistry
Pharmacology
Top 10 Co-Authors
Victor V Semenov
Marina N Semenova
Alex S Kiselyov
Leonid D Konyushkin
Dmitry V Tsyganov
Sergei I Firgang
Roman V Semenov
Natalia B Chernysheva
Ilia Y Titov
Alexander V Samet
Published In
Eur J Med Chem
J Nat Prod
Chem Biol Drug Des
J Med Chem
Bioorg Med Chem
Affiliations
Soon will be listed here.
Recent Articles
1.
Sea Urchin Embryo Model As a Reliable in Vivo Phenotypic Screen to Characterize Selective Antimitotic Molecules. Comparative evaluation of Combretapyrazoles, -isoxazoles, -1,2,3-triazoles, and -pyrroles as Tubulin-Binding Agents
Semenova M, Demchuk D, Tsyganov D, Chernysheva N, Samet A, Silyanova E, et al.
ACS Comb Sci . 2018 Nov; 20(12):700-721. PMID: 30452225
A series of both novel and reported combretastatin analogues, including diarylpyrazoles, -isoxazoles, -1,2,3-triazoles, and -pyrroles, were synthesized via improved protocols to evaluate their antimitotic antitubulin activity using in vivo sea...
2.
Efficient Synthesis of Glaziovianin A Isoflavone Series from Dill and Parsley Extracts and Their in Vitro/in Vivo Antimitotic Activity
Semenov V, Tsyganov D, Semenova M, Chuprov-Netochin R, Raihstat M, Konyushkin L, et al.
J Nat Prod . 2016 Apr; 79(5):1429-38. PMID: 27100701
A concise six-step protocol for the synthesis of isoflavone glaziovianin A (GVA) and its alkoxyphenyl derivatives 9 starting with readily available plant metabolites from dill and parsley seeds was developed....
3.
3-(5-)-Amino-o-diarylisoxazoles: regioselective synthesis and antitubulin activity
Tsyganov D, Khrustalev V, Konyushkin L, Raihstat M, Firgang S, Semenov R, et al.
Eur J Med Chem . 2014 Jan; 73:112-25. PMID: 24388833
A regioselective synthesis of both 5-amino- and 3-aminodiarylisoxazoles substituted with polyalkoxyaryl pharmacophores has been validated. Starting materials for the synthetic scheme were easily available from plant extracts. The targeted molecules...
4.
Synthesis and antiproliferative activity of conformationally restricted 1,2,3-triazole analogues of combretastatins in the sea urchin embryo model and against human cancer cell lines
Demchuk D, Samet A, Chernysheva N, Ushkarov V, Stashina G, Konyushkin L, et al.
Bioorg Med Chem . 2014 Jan; 22(2):738-55. PMID: 24387982
A series of 1,5-diaryl- and 4,5-diaryl-1,2,3-triazole derivatives of combretastatin A4 were synthesized and evaluated as antimitotic microtubule destabilizing agents using the sea urchin embryo model. Structure-activity relationship studies identified compounds...
5.
Polyalkoxybenzenes from plants. 5. Parsley seed extract in synthesis of azapodophyllotoxins featuring strong tubulin destabilizing activity in the sea urchin embryo and cell culture assays
Semenova M, Kiselyov A, Tsyganov D, Konyushkin L, Firgang S, Semenov R, et al.
J Med Chem . 2011 Sep; 54(20):7138-49. PMID: 21916509
A series of 4-azapodophyllotoxin derivatives with modified rings B and E have been synthesized using allylpolyalkoxybenzenes from parsley seed oil. The targeted molecules were evaluated in vivo in a phenotypic...
6.
Synthesis of antimitotic polyalkoxyphenyl derivatives of combretastatin using plant allylpolyalkoxybenzenes
Semenov V, Kiselyov A, Titov I, Sagamanova I, Ikizalp N, Chernysheva N, et al.
J Nat Prod . 2010 Nov; 73(11):1796-802. PMID: 21049975
No abstract available.
7.
Novel derivatives of 1,3,4-oxadiazoles are potent mitostatic agents featuring strong microtubule depolymerizing activity in the sea urchin embryo and cell culture assays
Kiselyov A, Semenova M, Chernyshova N, Leitao A, Samet A, Kislyi K, et al.
Eur J Med Chem . 2010 Jan; 45(5):1683-97. PMID: 20110137
A series of novel 1,3,4-oxadiazole derivatives based on structural and electronic overlap with combretastatins have been designed and synthesized. Initially, we tested all new compounds in vivo using the phenotypic...
8.
In vivo evaluation of indolyl glyoxamides in the phenotypic sea urchin embryo assay
Semenova M, Kiselyov A, Titov I, Raihstat M, Molodtsov M, Grishchuk E, et al.
Chem Biol Drug Des . 2007 Nov; 70(6):485-90. PMID: 17991295
We have devised a 'one-pot' phenotypic in vivo assay for the rapid evaluation of potential tubulin inhibitors using the sea urchin embryo model. An effect of a small molecule on...