Michele C Connelly
Overview
Explore the profile of Michele C Connelly including associated specialties, affiliations and a list of published articles.
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Articles
27
Citations
268
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Recent Articles
1.
Carrillo A, Kadayat T, Hwang J, Chen Y, Zhu F, Holbrook G, et al.
J Med Chem
. 2024 Feb;
67(5):3437-3447.
PMID: 38363074
Human African trypanosomiasis (HAT), a neglected tropical disease caused by () or (), remains a significant public health concern with over 55 million people at risk of infection. Current treatments...
2.
Mathew B, Snowden T, Connelly M, Guy R, Reynolds R
Bioorg Med Chem Lett
. 2018 May;
28(12):2136-2142.
PMID: 29776741
Non-steroidal anti-inflammatory drugs (NSAIDs) have a variety of potential indications that include management of pain and inflammation as well as chemoprevention and/or treatment of cancer. Furthermore, a specific form of...
3.
Mathew B, Hobrath J, Connelly M, Guy R, Reynolds R
Future Med Chem
. 2018 Apr;
10(7):743-753.
PMID: 29671617
Aim: Experimental and epidemiological studies and clinical trials suggest that nonsteroidal anti-inflammatory drugs possess antitumor potential. Sulindac, a widely used nonsteroidal anti-inflammatory drug, can prevent adenomatous colorectal polyps and colon...
4.
Hammill J, Scott D, Min J, Connelly M, Holbrook G, Zhu F, et al.
J Med Chem
. 2018 Mar;
61(7):2680-2693.
PMID: 29547696
We previously discovered and validated a class of piperidinyl ureas that regulate defective in cullin neddylation 1 (DCN1)-dependent neddylation of cullins. Here, we report preliminary structure-activity relationship studies aimed at...
5.
Hammill J, Bhasin D, Scott D, Min J, Chen Y, Lu Y, et al.
J Med Chem
. 2018 Mar;
61(7):2694-2706.
PMID: 29547693
We previously reported the discovery, validation, and structure-activity relationships of a series of piperidinyl ureas that potently inhibit the DCN1-UBE2M interaction. We demonstrated that compound 7 inhibits both the DCN1-UBE2M...
6.
Mathew B, Hobrath J, Connelly M, Guy R, Reynolds R
Open Med Chem J
. 2018 Mar;
12:1-12.
PMID: 29492166
Background: Sulindac belongs to the chemically diverse family of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) that effectively prevent adenomatous colorectal polyps and colon cancer, especially in patients with familial adenomatous polyposis. Sulindac...
7.
Mathew B, Hobrath J, Connelly M, Guy R, Reynolds R
Bioorg Med Chem Lett
. 2017 Sep;
27(20):4614-4621.
PMID: 28935266
Sulindac is a non-steroidal anti-inflammatory drug (NSAID) that has shown significant anticancer activity. Sulindac sulfide amide (1) possessing greatly reduced COX-related inhibition relative to sulindac displayed in vivo antitumor activity...
8.
Jarusiewicz J, Jeon J, Connelly M, Chen Y, Yang L, Baker S, et al.
ACS Omega
. 2017 Jun;
2(5):1985-2009.
PMID: 28580438
Profiling of the kinase-binding capabilities of an aminopyrimidine analogue detected in a cellular screen of the St. Jude small-molecule collection led to the identification of a novel series of FMS-like...
9.
Mathew B, Hobrath J, Ross L, Connelly M, Lofton H, Rajagopalan M, et al.
PLoS One
. 2016 Oct;
11(10):e0164100.
PMID: 27768711
A variety of commercial analogs and a newer series of Sulindac derivatives were screened for inhibition of M. tuberculosis (Mtb) in vitro and specifically as inhibitors of the essential mycobacterial...
10.
Min J, Guo K, Suryadevara P, Zhu F, Holbrook G, Chen Y, et al.
J Med Chem
. 2015 Dec;
59(2):559-77.
PMID: 26632965
We previously reported a novel inhibitor of the ataxia-telangiectasia mutated (ATM) kinase, which is a target for novel radiosensitizing drugs. While our initial lead, compound 4, was relatively potent and...