Bini Mathew
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Explore the profile of Bini Mathew including associated specialties, affiliations and a list of published articles.
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23
Citations
726
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Recent Articles
1.
Tinsley H, Mathew B, Chen X, Maxuitenko Y, Li N, Lowe W, et al.
Cancers (Basel)
. 2023 Feb;
15(3).
PMID: 36765604
The nonsteroidal anti-inflammatory drug (NSAID) sulindac demonstrates attractive anticancer activity, but the toxicity resulting from cyclooxygenase (COX) inhibition and the suppression of physiologically important prostaglandins precludes its long-term, high dose...
2.
Ghajar-Rahimi G, Traylor A, Mathew B, Bostwick J, Nebane N, Zmijewska A, et al.
Antioxidants (Basel)
. 2022 Oct;
11(10).
PMID: 36290611
Acute kidney injury (AKI) is a major public health concern with significant morbidity and mortality and no current treatments beyond supportive care and dialysis. Preclinical studies have suggested that heme-oxygenase-1...
3.
Yatchang M, Mathew B, Srivastava R, Khan J, Muzaffar S, Zhang S, et al.
Bioorg Med Chem Lett
. 2022 Mar;
64:128696.
PMID: 35318165
Arsenicals belong to the class of chemical warfare agents known as vesicants, which are highly reactive, toxic and cause robust inflammatory response. Cutaneous exposure to arsenicals causes a wide range...
4.
A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion
Sharma J, Du M, Wong E, Mutyam V, Li Y, Chen J, et al.
Nat Commun
. 2021 Jul;
12(1):4358.
PMID: 34272367
Premature termination codons (PTCs) prevent translation of a full-length protein and trigger nonsense-mediated mRNA decay (NMD). Nonsense suppression (also termed readthrough) therapy restores protein function by selectively suppressing translation termination...
5.
Mathew B, Ruiz P, Dutta S, Entrekin J, Zhang S, Patel K, et al.
Eur J Med Chem
. 2020 Nov;
210:112952.
PMID: 33139114
ALS is a rare type of progressive neurological disease with unknown etiology. It results in the gradual degeneration and death of motor neurons responsible for controlling the voluntary muscles. Identification...
6.
Suto M, Gupta V, Mathew B, Zhang W, Pallero M, Murphy-Ullrich J
ACS Med Chem Lett
. 2020 Jun;
11(6):1130-1136.
PMID: 32550992
TGF-β has been a target of interest for the treatment of fibrotic diseases and certain cancers. Approaches to target TGF-β include antagonists of the active ligand or TGF-β receptor kinase...
7.
Gibbons G, Chakraborty A, Grigsby S, Umeano A, Liao C, Moukha-Chafiq O, et al.
Eur J Med Chem
. 2020 Jan;
189:112023.
PMID: 31978781
Disruptor of Telomeric Silencing 1-Like (DOT1L), the sole histone H3 lysine 79 (H3K79) methyltransferase, is required for leukemogenic transformation in a subset of leukemias bearing chromosomal translocations of the Mixed...
8.
Mathew B, Ruiz P, Pathak V, Suto M
Bioorg Med Chem Lett
. 2020 Jan;
30(4):126950.
PMID: 31928838
Amyotrophic lateral sclerosis (ALS) is a rare and progressive neurodegenerative disease with unknown etiology. It is caused by the degeneration of motor neurons responsible for controlling voluntary muscles. It has...
9.
Mathew B, Snowden T, Connelly M, Guy R, Reynolds R
Bioorg Med Chem Lett
. 2018 May;
28(12):2136-2142.
PMID: 29776741
Non-steroidal anti-inflammatory drugs (NSAIDs) have a variety of potential indications that include management of pain and inflammation as well as chemoprevention and/or treatment of cancer. Furthermore, a specific form of...
10.
Mathew B, Hobrath J, Connelly M, Guy R, Reynolds R
Future Med Chem
. 2018 Apr;
10(7):743-753.
PMID: 29671617
Aim: Experimental and epidemiological studies and clinical trials suggest that nonsteroidal anti-inflammatory drugs possess antitumor potential. Sulindac, a widely used nonsteroidal anti-inflammatory drug, can prevent adenomatous colorectal polyps and colon...