Michel Bottlaender
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Explore the profile of Michel Bottlaender including associated specialties, affiliations and a list of published articles.
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127
Citations
2269
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Recent Articles
1.
Corvo C, Mendez-David I, Goutal S, Saba W, Bottlaender M, Caille F, et al.
ACS Pharmacol Transl Sci
. 2025 Feb;
8(2):339-345.
PMID: 39974650
In this preclinical pilot study, we used [C]UCB-J PET imaging to monitor the synaptic modulation in depression and after fluoxetine. PET imaging was performed in a validated mouse model of...
2.
Oomens J, van Gils V, Vos S, Freeze W, Maserejian N, Curiale G, et al.
JAMA Netw Open
. 2025 Jan;
8(1):e2455571.
PMID: 39841474
Importance: Baseline cerebral microbleeds (CMBs) and APOE ε4 allele copy number are important risk factors for amyloid-related imaging abnormalities in patients with Alzheimer disease (AD) receiving therapies to lower amyloid-β...
3.
Wiels W, Oomens J, Engelborghs S, Baeken C, von Arnim C, Boada M, et al.
JAMA Psychiatry
. 2025 Jan;
82(3):296-310.
PMID: 39841452
Importance: Depressive symptoms are associated with cognitive decline in older individuals. Uncertainty about underlying mechanisms hampers diagnostic and therapeutic efforts. This large-scale study aimed to elucidate the association between depressive...
4.
Sigaut S, Tardivon C, Jacquens A, Bottlaender M, Gervais P, Habert M, et al.
BMJ Open
. 2024 Dec;
14(12):e091441.
PMID: 39740941
Introduction: Traumatic brain injury (TBI) is one of the leading causes of death and disability worldwide. Treatments for TBI patients are limited and none has been shown to provide prolonged...
5.
Kilmer J, Rodrigo S, Petrescu A, Aghakhani N, Herbrecht A, Leroy C, et al.
Epilepsia
. 2024 Dec;
66(2):430-443.
PMID: 39679816
Objectives: Resective surgery in drug-resistant focal epilepsy (DRFE) requires extensive evaluation to localize the epileptogenic zone (EZ). When non-invasive phase 1 assessments (electroencephalography, EEG; magnetic resonance imaging, MRI; and F-Fluorodeoxyglucose-positron...
6.
Garland E, Antony H, Kulagowska L, Scott T, Rogien C, Bottlaender M, et al.
Acta Neuropathol
. 2024 Nov;
148(1):62.
PMID: 39540994
Translocator protein (TSPO) is a mitochondrial protein expressed by microglia, ligands for which are used as a marker of neuroinflammation in PET studies of Alzheimer's disease (AD). We previously showed...
7.
Guevara M, Roche S, Brochard V, Cam D, Badagbon J, Leprince Y, et al.
Front Neuroimaging
. 2024 Nov;
3:1359630.
PMID: 39498389
Background: Iron accumulates in the brain during aging and is the focus of intensive research as an abnormal load, particularly in Deep Gray Matter (DGM), is related to neurodegeneration. Magnetic...
8.
Auvity S, Attili B, Caille F, Goislard M, Cayla J, Hinnen F, et al.
ACS Pharmacol Transl Sci
. 2024 Oct;
7(10):3144-3154.
PMID: 39421654
We have previously developed seven fluorinated analogues of A-836339 as new PET tracers for cannabinoid type 2 receptor (CBR) imaging, among which ()--(3-(2-(2-[F]fluoroethoxy)ethyl)-4,5-dimethylthiazol-2(3)-ylidene)-2,2,3,3-tetramethylcyclopropane-1-carboxamide ([F]FC0324) displayed high affinity and selectivity for...
9.
Boulant N, Mauconduit F, Gras V, Amadon A, Le Ster C, Luong M, et al.
Nat Methods
. 2024 Oct;
21(11):2013-2016.
PMID: 39420141
The understanding of the human brain is one of the main scientific challenges of the twenty-first century. In the early 2000s, the French Atomic Energy Commission launched a program to...
10.
Lebrun A, Leprince Y, Lagarde J, Olivieri P, Moussion M, Noiray C, et al.
Alzheimers Dement
. 2024 Aug;
20(10):6922-6934.
PMID: 39193664
Introduction: Typical Alzheimer's disease (AD) and limbic-predominant age-related TAR DNA-binding protein 43 (TDP-43) encephalopathy (LATE) are two neurodegenerative diseases that present with a similar initial amnestic clinical phenotype but are...