Julien Lagarde
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Explore the profile of Julien Lagarde including associated specialties, affiliations and a list of published articles.
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93
Citations
14861
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Recent Articles
1.
Katsumi Y, Touroutoglou A, Brickhouse M, Eloyan A, Eckbo R, Zaitsev A, et al.
Alzheimers Dement
. 2025 Feb;
21(2):e14489.
PMID: 39968692
Introduction: Early-onset and late-onset Alzheimer's disease (EOAD and LOAD, respectively) have distinct clinical manifestations, with prior work based on small samples suggesting unique patterns of neurodegeneration. The current study performed...
2.
Oomens J, van Gils V, Vos S, Freeze W, Maserejian N, Curiale G, et al.
JAMA Netw Open
. 2025 Jan;
8(1):e2455571.
PMID: 39841474
Importance: Baseline cerebral microbleeds (CMBs) and APOE ε4 allele copy number are important risk factors for amyloid-related imaging abnormalities in patients with Alzheimer disease (AD) receiving therapies to lower amyloid-β...
3.
Wiels W, Oomens J, Engelborghs S, Baeken C, von Arnim C, Boada M, et al.
JAMA Psychiatry
. 2025 Jan;
82(3):296-310.
PMID: 39841452
Importance: Depressive symptoms are associated with cognitive decline in older individuals. Uncertainty about underlying mechanisms hampers diagnostic and therapeutic efforts. This large-scale study aimed to elucidate the association between depressive...
4.
Hammers D, Eloyan A, Taurone A, Thangarajah M, Gao S, Beckett L, et al.
Alzheimers Dement
. 2024 Dec;
21(2):e14439.
PMID: 39713873
Introduction: Early-onset Alzheimer's disease (EOAD) manifests prior to the age of 65, and affects 4%-8% of patients with Alzheimer's disease (AD). The current analyses sought to examine longitudinal cognitive trajectories...
5.
Hammers D, Eloyan A, Thangarajah M, Taurone A, Beckett L, Gao S, et al.
Alzheimers Dement
. 2024 Dec;
21(1):e14218.
PMID: 39711228
Introduction: Early-onset Alzheimer's disease (EOAD) and late-onset Alzheimer's disease (LOAD) share similar amyloid etiology, but evidence from smaller-scale studies suggests that they manifest differently clinically. Current analyses sought to contrast...
6.
Kaur G, Perteghella T, Carbonell-Sala S, Gonzalez-Martinez J, Hunt T, Madry T, et al.
bioRxiv
. 2024 Nov;
PMID: 39554180
Accurate and complete gene annotations are indispensable for understanding how genome sequences encode biological functions. For twenty years, the GENCODE consortium has developed reference annotations for the human and mouse...
7.
Lebrun A, Leprince Y, Lagarde J, Olivieri P, Moussion M, Noiray C, et al.
Alzheimers Dement
. 2024 Aug;
20(10):6922-6934.
PMID: 39193664
Introduction: Typical Alzheimer's disease (AD) and limbic-predominant age-related TAR DNA-binding protein 43 (TDP-43) encephalopathy (LATE) are two neurodegenerative diseases that present with a similar initial amnestic clinical phenotype but are...
8.
Carbonell-Sala S, Perteghella T, Lagarde J, Nishiyori H, Palumbo E, Arnan C, et al.
Nat Commun
. 2024 Jun;
15(1):5278.
PMID: 38937428
Long-read RNA sequencing is essential to produce accurate and exhaustive annotation of eukaryotic genomes. Despite advancements in throughput and accuracy, achieving reliable end-to-end identification of RNA transcripts remains a challenge...
9.
Eysert F, Kinoshita P, Lagarde J, Lacas-Gervais S, Xicota L, Dorothee G, et al.
Acta Neuropathol Commun
. 2024 Jun;
12(1):90.
PMID: 38851733
Mitochondrial dysfunctions are key features of Alzheimer's disease (AD). The occurrence of these disturbances in the peripheral cells of AD patients and their potential correlation with disease progression are underinvestigated....
10.
Pardo-Palacios F, Wang D, Reese F, Diekhans M, Carbonell-Sala S, Williams B, et al.
Nat Methods
. 2024 Jun;
21(7):1349-1363.
PMID: 38849569
The Long-read RNA-Seq Genome Annotation Assessment Project Consortium was formed to evaluate the effectiveness of long-read approaches for transcriptome analysis. Using different protocols and sequencing platforms, the consortium generated over...