Synaptic Vesicle 2A (SV2A) Positron Emission Tomography (PET) Imaging As a Marker of Therapeutic Response in a Mouse Model of Depression

Overview

Journal ACS Pharmacol Transl Sci

Publisher American Chemical Society

Specialty Biochemistry

Date 2025 Feb 20

PMID 39974650

Authors

Cassandre Corvo

Indira Mendez-David

Sebastien Goutal

Wadad Saba

Michel Bottlaender

Fabien Caille

Rene Hen

Romain Colle

Emmanuelle Corruble

Nicolas Tournier

Claire Leroy

Denis J David

Affiliations

Soon will be listed here.

Abstract

In this preclinical pilot study, we used [C]UCB-J PET imaging to monitor the synaptic modulation in depression and after fluoxetine. PET imaging was performed in a validated mouse model of depression/anxiety (CORT model), and the effect of 5-week treatment with fluoxetine was tested. Depression/anxiety phenotype and antidepressant action of fluoxetine were confirmed using the novelty-suppressed feeding test, previously validated in the CORT model. PET data showed significant decreases of volume of distribution ( ) of [C]UCB-J in most brain regions of CORT mice compared with controls. After 5 weeks of fluoxetine, a trend toward restoration of values to control levels was observed, although it reached significance only in the olfactory bulb. These preliminary data support the use of [C]UCB-J PET imaging and the CORT model to study the synaptic modulation of antidepressants. It provides excellent translational opportunities to study the relationship between synaptic plasticity and the clinical efficacy of antidepressants.

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