Michaela Matthey
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Explore the profile of Michaela Matthey including associated specialties, affiliations and a list of published articles.
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17
Citations
245
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Recent Articles
1.
Seidinger A, Roberts R, Bai Y, Muller M, Pfeil E, Matthey M, et al.
EMBO Mol Med
. 2024 Jul;
16(8):1930-1956.
PMID: 38977926
Pulmonary arterial hypertension (PAH) is a life-threatening disease with limited survival. Herein, we propose the pharmacological inhibition of Gq proteins as a novel concept to counteract pulmonary vasoconstriction and proliferation/migration...
2.
Bruckner A, Brandtner A, Rieck S, Matthey M, Geisen C, Fels B, et al.
Angiogenesis
. 2024 Jul;
27(4):719-738.
PMID: 38965173
Aortic aneurysm is characterized by a pathological dilation at specific predilection sites of the vessel and potentially results in life-threatening vascular rupture. Herein, we established a modified "Häutchen method" for...
3.
Simon A, von Einem T, Seidinger A, Matthey M, Bindila L, Wenzel D
Nat Commun
. 2022 Nov;
13(1):6941.
PMID: 36396957
Chronic obstructive airway diseases are a global medical burden that is expected to increase in the near future. However, the underlying mechanistic processes are poorly understood so far. Herein, we...
4.
Ghigo A, Murabito A, Sala V, Pisano A, Bertolini S, Gianotti A, et al.
Sci Transl Med
. 2022 Mar;
14(638):eabl6328.
PMID: 35353541
Cyclic adenosine 3',5'-monophosphate (cAMP)-elevating agents, such as β-adrenergic receptor (β-AR) agonists and phosphodiesterase (PDE) inhibitors, remain a mainstay in the treatment of obstructive respiratory diseases, conditions characterized by airway constriction,...
5.
Rieck S, Kilgus S, Meyer J, Huang H, Zhao L, Matthey M, et al.
Arterioscler Thromb Vasc Biol
. 2021 Oct;
41(12):2974-2989.
PMID: 34615374
Objective: Pathological angiogenesis is a hallmark of various diseases characterized by local hypoxia and inflammation. These disorders can be treated with inhibitors of angiogenesis, but current compounds display a variety...
6.
Schlegel J, Tahoun M, Seidinger A, Voss J, Kuschak M, Kehraus S, et al.
ACS Pharmacol Transl Sci
. 2021 Apr;
4(2):888-897.
PMID: 33860209
Guanine nucleotide-binding proteins (G proteins) transduce extracellular signals received by G protein-coupled receptors (GPCRs) to intracellular signaling cascades. While GPCRs represent the largest class of drug targets, G protein inhibition...
7.
Pfeil E, Brands J, Merten N, Vogtle T, Vescovo M, Rick U, et al.
Mol Cell
. 2020 Nov;
80(6):940-954.e6.
PMID: 33202251
Mechanisms that control mobilization of cytosolic calcium [Ca] are key for regulation of numerous eukaryotic cell functions. One such paradigmatic mechanism involves activation of phospholipase Cβ (PLCβ) enzymes by G...
8.
Kuschak M, Schlegel J, Schneider M, Kehraus S, Voss J, Seidinger A, et al.
Front Chem
. 2020 Nov;
8:833.
PMID: 33173765
The cyclic depsipeptide FR900359 (FR) isolated from the plant and produced by endosymbiotic bacteria acts as a selective Gq protein inhibitor. It is a powerful tool to study G protein-coupled...
9.
Kuschak M, Namasivayam V, Rafehi M, Voss J, Garg J, Schlegel J, et al.
Br J Pharmacol
. 2019 Dec;
177(8):1898-1916.
PMID: 31881095
Background And Purpose: G proteins are intracellular switches that transduce and amplify extracellular signals from GPCRs. The G protein subtypes, which are coupled to PLC activation, can act as oncogenes,...
10.
Neumann V, Knies R, Seidinger A, Simon A, Lorenz K, Matthey M, et al.
FASEB J
. 2018 Jan;
32(5):2519-2530.
PMID: 29295855
Pulmonary hypertension is a severe, incurable disease with a poor prognosis. Although treatment regimens have improved during the last 2 decades, current pharmacologic strategies are limited and focus on the...