Michael Willem
Overview
Explore the profile of Michael Willem including associated specialties, affiliations and a list of published articles.
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70
Citations
4011
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Recent Articles
1.
Jocher G, Ozcelik G, Muller S, Hsia H, Lastra Osua M, Hofmann L, et al.
Life Sci Alliance
. 2025 Mar;
8(5).
PMID: 40081988
The cell surface receptor TREM2 is a key genetic risk factor and drug target in Alzheimer's disease (AD). In the brain, TREM2 is expressed in microglia, where it undergoes proteolytic...
2.
Kaji S, Berghoff S, Spieth L, Schlaphoff L, Sasmita A, Vitale S, et al.
Immunity
. 2024 Dec;
58(1):263.
PMID: 39637851
No abstract available.
3.
Shojaei M, Schaefer R, Schlepckow K, Kunze L, Struebing F, Brunner B, et al.
Theranostics
. 2024 Oct;
14(16):6319-6336.
PMID: 39431020
Triggering receptor expressed on myeloid cells 2 (TREM2) plays an essential role in microglia activation and is being investigated as a potential therapeutic target for modulation of microglia in several...
4.
Kaji S, Berghoff S, Spieth L, Schlaphoff L, Sasmita A, Vitale S, et al.
Immunity
. 2024 Oct;
57(11):2651-2668.e12.
PMID: 39419029
The seeded growth of pathogenic protein aggregates underlies the pathogenesis of Alzheimer's disease (AD), but how this pathological cascade is initiated is not fully understood. Sporadic AD is linked genetically...
5.
Zatcepin A, Gnorich J, Rauchmann B, Bartos L, Wagner S, Franzmeier N, et al.
Mol Neurodegener
. 2024 Sep;
19(1):64.
PMID: 39238030
Background: Microglial activation is one hallmark of Alzheimer disease (AD) neuropathology but the impact of the regional interplay of microglia cells in the brain is poorly understood. We hypothesized that...
6.
Parhizkar S, Arzberger T, Brendel M, Kleinberger G, Deussing M, Focke C, et al.
Nat Neurosci
. 2024 Aug;
27(9):1858-1859.
PMID: 39143410
No abstract available.
7.
Dunot J, Moreno S, Gandin C, Pousinha P, Amici M, Dupuis J, et al.
Neuron
. 2024 Jun;
112(16):2708-2720.e9.
PMID: 38878768
NMDA receptors (NMDARs) are ionotropic receptors crucial for brain information processing. Yet, evidence also supports an ion-flux-independent signaling mode mediating synaptic long-term depression (LTD) and spine shrinkage. Here, we identify...
8.
Depp C, Sun T, Sasmita A, Spieth L, Berghoff S, Nazarenko T, et al.
Nature
. 2023 May;
618(7964):349-357.
PMID: 37258678
The incidence of Alzheimer's disease (AD), the leading cause of dementia, increases rapidly with age, but why age constitutes the main risk factor is still poorly understood. Brain ageing affects...
9.
Krammer C, Yang B, Reichl S, Besson-Girard S, Ji H, Bolini V, et al.
FASEB J
. 2023 Feb;
37(3):e22752.
PMID: 36794636
Atherosclerosis is a chronic inflammatory condition of our arteries and the main underlying pathology of myocardial infarction and stroke. The pathogenesis is age-dependent, but the links between disease progression, age,...
10.
Rajao-Saraiva J, Dunot J, Ribera A, Temido-Ferreira M, Coelho J, Konig S, et al.
Aging Cell
. 2023 Jan;
22(3):e13778.
PMID: 36704841
N-methyl-D-aspartate receptors (NMDARs) are critical for the maturation and plasticity of glutamatergic synapses. In the hippocampus, NMDARs mainly contain GluN2A and/or GluN2B regulatory subunits. The amyloid precursor protein (APP) has...