Michael Weinfeld
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Explore the profile of Michael Weinfeld including associated specialties, affiliations and a list of published articles.
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Articles
114
Citations
2848
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Recent Articles
1.
Mehinrad P, Abdelfattah A, Sadat S, Shafaati T, Elmenoufy A, Jay D, et al.
Drug Deliv Transl Res
. 2025 Jan;
PMID: 39878858
In this study, a novel inhibitor of ERCC1/XPF heterodimerization, A4, was used as an inhibitor of repair for DNA damage by platinum-based chemotherapeutics. Nano-formulations of A4 were developed, using self-assembly...
2.
Mashayekhi F, Ganje C, Caron M, Heyza J, Gao Y, Zeinali E, et al.
Cell Rep
. 2024 Dec;
43(12):115066.
PMID: 39671289
Uncontrolled degradation and collapse of stalled replication forks (RFs) are primary sources of genomic instability, yet the molecular mechanisms for protecting forks from degradation/collapse remain to be fully elaborated. Here,...
3.
Ciniero G, Pedro T, Dumontet C, Elmenoufy A, West F, Weinfeld M, et al.
Fundam Clin Pharmacol
. 2024 Nov;
39(1):e13043.
PMID: 39520092
Background: DNA repair plays a major role in maintaining genomic stability, thus limiting the transformation of normal cells into cancer cells. However, in cancer patients treated with DNA-targeting drugs, DNA...
4.
Mashayekhi F, Zeinali E, Ganje C, Fanta M, Li L, Godbout R, et al.
J Biol Chem
. 2024 Oct;
300(11):107880.
PMID: 39395804
Okazaki fragment maturation (OFM) stands as a pivotal DNA metabolic process, crucial for genome integrity and cell viability. Dysregulation of OFM leads to DNA single-strand breaks-accumulation, which is linked to...
5.
Pandey P, Chaudhary R, Tripathi D, Lavudi K, Dua K, Weinfeld M, et al.
Med Oncol
. 2024 Sep;
41(11):252.
PMID: 39320608
Breast cancer (BC) is a leading global concern for women, with 30% being HER2-positive cases linked to poorer outcomes. Targeted therapies like trastuzumab deruxtecan (T-DXd), trastuzumab, pertuzumab, and T-DM1 have...
6.
Tao J, Zhang H, Weinfeld M, Le X
ACS Meas Sci Au
. 2024 Aug;
4(4):459-466.
PMID: 39184356
DNA glycosylase dysregulation is implicated in carcinogenesis and therapeutic resistance of cancers. Thus, various DNA-based detection platforms have been developed by leveraging the base excision activity of DNA glycosylases. However,...
7.
Kate W, Fanta M, Weinfeld M
Nucleic Acids Res
. 2024 Aug;
52(16):9630-9653.
PMID: 39087523
DNA damage has been implicated in the stimulation of the type 1 interferon (T1IFN) response. Here, we show that downregulation of the DNA repair protein, polynucleotide kinase/phosphatase (PNKP), in a...
8.
Goodhead D, Weinfeld M
Radiat Res
. 2024 Jul;
202(2):385-407.
PMID: 38954537
The concept of radiation-induced clustered damage in DNA has grown over the past several decades to become a topic of considerable interest across the scientific disciplines involved in studies of...
9.
Sadat S, Vakili M, Abd-El Hafeez S, Paladino M, Hall D, Weinfeld M, et al.
Mol Pharm
. 2024 May;
21(7):3240-3255.
PMID: 38785196
Inhibitors of a DNA repair enzyme known as polynucleotide kinase 3'-phosphatase (PNKP) are expected to show synergistic cytotoxicity in combination with topoisomerase I (TOP1) inhibitors in cancer. In this study,...
10.
Feng W, Peng H, Zhang H, Weinfeld M, Le X
Angew Chem Int Ed Engl
. 2024 Mar;
63(22):e202404069.
PMID: 38526321
Activation of the CRISPR-Cas13a system requires the formation of a crRNA-Cas13a ribonucleoprotein (RNP) complex and the binding of an RNA activator to the RNP. These two binding processes play a...