Michael U Shiloh
Overview
Explore the profile of Michael U Shiloh including associated specialties, affiliations and a list of published articles.
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28
Citations
1572
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Recent Articles
1.
Alvarez-Arguedas S, Mazhar K, Wangzhou A, Sankaranarayanan I, Gaona G, Lafin J, et al.
bioRxiv
. 2024 Nov;
PMID: 39484391
The nasal, oropharyngeal, and bronchial mucosa are primary contact points for airborne pathogens like (Mtb), SARS-CoV-2, and influenza virus. While mucosal surfaces can function as both entry points and barriers...
2.
Ektnitphong V, Dias B, Campos P, Shiloh M
bioRxiv
. 2024 Sep;
PMID: 39257817
Lung disease due to non-tuberculous mycobacteria (NTM) is rising in incidence. While both two dimensional cell culture and animal models exist for NTM infections, a major knowledge gap is the...
3.
Guzman L, Cambier C, Cheng T, Naqvi K, Shiloh M, Moody D, et al.
ACS Chem Biol
. 2024 Mar;
19(3):707-717.
PMID: 38442242
Surface lipids on pathogenic mycobacteria modulate infection outcomes by regulating host immune responses. Phenolic glycolipid (PGL) is a host-modulating surface lipid that varies among clinical strains. PGL is also found...
4.
Thinwa J, Zou Z, Parks E, Sebti S, Hui K, Wei Y, et al.
J Clin Invest
. 2023 Nov;
134(1).
PMID: 37917202
Virophagy, the selective autophagosomal engulfment and lysosomal degradation of viral components, is crucial for neuronal cell survival and antiviral immunity. However, the mechanisms leading to viral antigen recognition and capture...
5.
Rahlwes K, Dias B, Campos P, Alvarez-Arguedas S, Shiloh M
Virulence
. 2022 Nov;
14(1):2150449.
PMID: 36419223
(Mtb) is the causative agent of tuberculosis, an infectious disease with one of the highest morbidity and mortality rates worldwide. Leveraging its highly evolved repertoire of non-protein and protein virulence...
6.
Naqvi K, Mazzone S, Shiloh M
Annu Rev Physiol
. 2022 Sep;
85:71-91.
PMID: 36170660
Coughing is a dynamic physiological process resulting from input of vagal sensory neurons innervating the airways and perceived airway irritation. Although cough serves to protect and clear the airways, it...
7.
Sebti S, Zou Z, Shiloh M
Autophagy
. 2022 Aug;
19(3):957-965.
PMID: 35993269
Macroautophagy/autophagy is necessary for lifespan extension in multiple model organisms and autophagy dysfunction impacts age-related phenotypes and diseases. Introduction of an F121A mutation into the essential autophagy protein BECN1 constitutively...
8.
Campos P, Cunha D, Souza-Costa L, Shiloh M, Franco L
Trends Microbiol
. 2022 May;
30(10):973-985.
PMID: 35491351
Infection with Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis (TB), remains a significant global epidemic. Host resistance to Mtb depends on both adaptive and innate immunity mechanisms, including development...
9.
Ruhl C, Pasko B, Khan H, Kindt L, Stamm C, Franco L, et al.
Cell
. 2020 Mar;
181(2):293-305.e11.
PMID: 32142653
Pulmonary tuberculosis, a disease caused by Mycobacterium tuberculosis (Mtb), manifests with a persistent cough as both a primary symptom and mechanism of transmission. The cough reflex can be triggered by...
10.
Khan H, Nair V, Ruhl C, Alvarez-Arguedas S, Galvan Rendiz J, Franco L, et al.
Elife
. 2020 Mar;
9.
PMID: 32134383
(Mtb) can enter the body through multiple routes, including via specialized transcytotic cells called microfold cells (M cell). However, the mechanistic basis for M cell entry remains undefined. Here, we...