Michael S Lan
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Explore the profile of Michael S Lan including associated specialties, affiliations and a list of published articles.
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44
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827
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Recent Articles
1.
Lan M, Chen C
Biology (Basel)
. 2023 Aug;
12(8).
PMID: 37627018
Human neuroblastoma (NB) is the most common childhood extracranial tumor arising from the sympathetic nervous system. It is also a clinically heterogeneous disease that ranges from spontaneous regression to high-risk...
2.
Chen C, Wu J, Hicks C, Lan M
Cell Signal
. 2023 Jun;
109:110753.
PMID: 37301315
High-risk neuroblastoma (NB) is a heterogeneous and malignant childhood cancer that is frequently characterized by MYCN proto-oncogene amplification or elevated N-Myc protein (N-Myc) expression. An N-Myc downstream target gene, insulinoma...
3.
Chen C, Lan M
Biology (Basel)
. 2022 Oct;
11(10).
PMID: 36290282
An aggressive form of neuroblastoma (NB), a malignant childhood cancer derived from granule neuron precursors and sympathoadrenal lineage, frequently comprises amplification/elevated N-Myc expression, which contributes to the development of neural...
4.
Chen C, Lan M
Cell Signal
. 2020 Sep;
76:109785.
PMID: 32966884
Aggressive form of neuroblastoma (NB) is a malignant childhood cancer derived from granule neuron precursors and sympatho-adrenal lineage with N-MYC amplification. An insulinoma associated-1 (INSM1) transcription factor has emerged as...
5.
Chen C, Notkins A, Lan M
Mol Cancer Res
. 2019 May;
17(8):1597-1604.
PMID: 31113827
Insulinoma-associated-1 (IA-1 or INSM1) encodes a zinc-finger transcription factor, which was isolated from a human insulinoma subtraction library, with specific expression patterns, predominantly in developing neuroendocrine tissues and tumors. INSM1...
6.
Chen C, Breslin M, Guidry J, Lan M
J Biol Chem
. 2019 Feb;
294(14):5456-5465.
PMID: 30755485
Insulinoma-associated-1 (INSM1) is a key protein functioning as a transcriptional repressor in neuroendocrine differentiation and is activated by N-Myc in human neuroblastoma (NB). INSM1 modulates the phosphoinositide 3-kinase (PI3K)-AKT Ser/Thr...
7.
Wang L, Sun Z, Xiang B, Wei C, Wang Y, Sun K, et al.
J Transl Med
. 2018 Oct;
16(1):297.
PMID: 30359270
Background: Neurogenin3 (Ngn3) and neurogenic differentiation 1 (NeuroD1), two crucial transcriptional factors involved in human diabetes (OMIM: 601724) and islet development, have been previously found to directly target to the...
8.
Chen C, Breslin M, Lan M
Cell Signal
. 2018 Mar;
46:83-91.
PMID: 29501727
Neuroendocrine (NE) lung tumors account for 20% of total lung cancer cases and represent a subset of aggressive tumors with metastatic potential. High-risk NE lung cancer patients display disseminated disease,...
9.
Chen C, Chang Y, Lan M, Breslin M
Int J Oncol
. 2016 Jun;
49(2):847.
PMID: 27279381
Following the publication of this article, an interested reader drew to our attention an anomaly associated with the presentation of Figs. 5 and 8; essentially, the β-actin control bands in...
10.
Chen C, Breslin M, Lan M
BMC Pulm Med
. 2016 Apr;
16:49.
PMID: 27072116
Background: Insulinoma associated-1 (INSM1) gene is expressed exclusively in early embryonic neuroendocrine tissues, but has been found highly re-activated in most of the neuroendocrine tumors including small cell lung carcinoma....