Michael R McNeil
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Explore the profile of Michael R McNeil including associated specialties, affiliations and a list of published articles.
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71
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2141
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Recent Articles
1.
Angala S, Li W, Boot C, Jackson M, McNeil M
Commun Chem
. 2021 Jul;
3(1).
PMID: 34295997
Mycobacterial lipoarabinomannan (LAM) in an essential cell envelope lipopolysaccharide anchored both to the plasma and outer membranes. To understand critical biological questions such as the biosynthesis, spatial organization of LAM...
2.
Angala S, Joe M, McNeil M, Liav A, Lowary T, Jackson M
ACS Chem Biol
. 2020 Dec;
16(1):20-26.
PMID: 33382235
The arabinogalactan of is a critical heteropolysaccharide that tethers outer membrane mycolic acids to peptidoglycan thus forming the characteristic cell wall core of these prokaryotes. An essential α-(1→5)-arabinosyltransferase, AftA, is...
3.
Garcia E, Blanco F, Klepp L, Pazos A, McNeil M, Jackson M, et al.
Comp Immunol Microbiol Infect Dis
. 2020 Dec;
74:101593.
PMID: 33285386
PhoP is part of the two-component PhoPR system that regulates the expression of virulence genes of Mycobacteria. The goal of this work was to elucidate the role of PhoP in...
4.
Grzegorzewicz A, Lelievre J, Esquivias J, Angala B, Liu J, Lee R, et al.
Antimicrob Agents Chemother
. 2020 Nov;
65(1).
PMID: 33139282
Phenotypic screening of inhibitors of the essential FAS-II dehydratase HadAB led to the identification of GSK3011724A, a compound previously reported to inhibit the condensation step of FAS-II. Whole-cell-based and cell-free...
5.
Wiersma C, Belardinelli J, Avanzi C, Angala S, Everall I, Angala B, et al.
ACS Infect Dis
. 2020 Jun;
6(8):2143-2154.
PMID: 32551551
Understanding the physiological processes underlying the ability of to become a chronic pathogen of the cystic fibrosis (CF) lung is important to the development of prophylactic and therapeutic strategies to...
6.
Angala S, Li W, Palcekova Z, Zou L, Lowary T, McNeil M, et al.
Int J Mol Sci
. 2019 Dec;
20(24).
PMID: 31835712
Mycobacteria produce two major lipoglycans, lipomannan (LM) and lipoarabinomannan (LAM), whose broad array of biological activities are tightly related to the fine details of their structure. However, the heterogeneity of...
7.
Grzegorzewicz A, Gee C, Das S, Liu J, Belardinelli J, Jones V, et al.
ACS Infect Dis
. 2019 Nov;
6(2):195-204.
PMID: 31775512
Isoxyl (ISO) and thiacetazone (TAC) are two antitubercular prodrugs that abolish mycolic acid biosynthesis and kill () through the inhibition of the essential type II fatty acid synthase (FAS-II) dehydratase...
8.
Upadhyay A, Kumar S, Rooker S, Koehn J, Crans D, McNeil M, et al.
ACS Chem Biol
. 2018 Aug;
13(9):2498-2507.
PMID: 30091899
MenJ, annotated as an oxidoreductase, was recently demonstrated to catalyze the reduction (saturation) of a single double bond in the isoprenyl side-chain of mycobacterial menaquinone. This modification was shown to...
9.
Samanovic M, Hsu H, Jones M, Jones V, McNeil M, Becker S, et al.
mBio
. 2018 Jun;
9(3).
PMID: 29921668
It was recently reported that the human-exclusive pathogen secretes cytokinins, which had only been known as plant hormones. While cytokinins are well-established, adenine-based signaling molecules in plants, they have never...
10.
Davidson R, DeGroote M, Marola J, Buss S, Jones V, McNeil M, et al.
Int J Syst Evol Microbiol
. 2017 Aug;
67(8):2640-2645.
PMID: 28809146
A novel slowly growing, non-chromogenic species of the class Actinobacteria was isolated from a human respiratory sample in Nebraska, USA, in 2012. Analysis of the internal transcribed spacer sequence supported...