General Control Nonderepressible 2 (GCN2) As a Therapeutic Target in Age-related Diseases

Overview

Journal Front Aging

Specialty Geriatrics

Date 2024 Sep 25

PMID 39319345

Authors

Ozlem Altintas

Michael R MacArthur

Affiliations

Soon will be listed here.

Abstract

The function of General Control Nonderepressible 2 (GCN2), an evolutionary-conserved component of the integrated stress response (ISR), has been well-documented across organisms from yeast to mammals. Recently GCN2 has also gained attention for its role in health and disease states. In this review, we provide a brief overview of GCN2, including its structure, activation mechanisms and interacting partners, and explore its potential significance as a therapeutic target in various age-related diseases including neurodegeneration, inflammatory disorders and cancer. Finally, we summarize the barriers to effectively targeting GCN2 for the treatment of disease and to promote a healthier aging process.

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